NDLI: Tobacco smoking, family history, and the risk of nasopharyngeal carcinoma: a case

Content Provider	Springer Nature Link
Author	Xie, Shao Hua Yu, Ignatius Tak sun Tse, Lap Ah Au, Joseph Siu Kie Lau, June Sze Man
Copyright Year	2015
Abstract	This study aimed to investigate the associations of tobacco smoking and family history of nasopharyngeal carcinoma (NPC) with the risk of NPC in Hong Kong Chinese. Between June 2010 and December 2012, we conducted a case–referent study with 352 incident cases and 410 referents in Hong Kong. We collected information on tobacco smoking and family history of NPC via face-to-face interviews. There were 174 (49.4 %) and 131 (32.0 %) ever-smokers among cases and referents, respectively. The adjusted odds ratio (OR) for NPC related to current smoking was 1.67 [95 % confidence interval (CI) 1.06, 2.61]. Exposure–response relationships were observed between years and total pack-years of smoking, and NPC risk (p = 0.001 and p = 0.018, respectively). History of NPC in first-degree relatives was associated with an increased NPC risk (adjusted OR = 4.52, 95 % CI 2.39, 8.55). The increased NPC risk associated with sibling history (adjusted OR = 6.80, 95 % CI 2.63, 17.56) was higher than that for parental history (adjusted OR = 3.04, 95 % CI 1.27, 7.25). The adjusted OR for ever-smokers with family history using never-smokers without family history as the reference was 4.54 (95 % CI 1.67, 12.34).This study verified the important roles of tobacco smoking and family history on NPC risk among Hong Kong Chinese. The provided evidence supported the knowledge that both environmental exposures and inherited susceptibility contributed to the risk of NPC.
Starting Page	913
Ending Page	921
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-03-31
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tobacco smoking Nasopharyngeal carcinoma Family history Etiology Epidemiology Risk factor Cancer Research Biomedicine general Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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