NDLI: Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case

Content Provider	Springer Nature Link
Author	Greep, Kathryn R. Miller, Margaret Bailey, Helen D. Klerk, Nicholas H. Attia, John Kellie, Stewart J. Bower, Carol Armstrong, Bruce K. Milne, Elizabeth
Copyright Year	2015
Abstract	The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case–control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3–14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis.Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95 % confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95 % confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat.High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.
Starting Page	871
Ending Page	879
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-03-20
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Child Brain tumors Folate Neoplasms Micronutrients Processed meat Vitamins Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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