NDLI: Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand

Content Provider	Springer Nature Link
Author	Fachiroh, Jajah Sangrajrang, Suleeporn Johansson, Mattias Renard, Hélène Gaborieau, Valérie Chabrier, Amélie Chindavijak, Somjin Brennan, Paul McKay, James D.
Copyright Year	2012
Abstract	The incidence of nasopharyngeal carcinoma (NPC) varies substantially worldwide, with an endemic pocket in Southeast Asia.We assessed lifestyle and genetic factors in relation to NPC risk among 681 NPC cases and 1,078 controls from Thailand. Evaluated lifestyle factors included traditionally preserved foods, tobacco smoking, betel quid chewing, and alcohol consumption. Genetic factors included six variants implicated in a previous a genome-wide association study (GWAS) of NPC and three variants residing near the CHRNA3 and TERT genes that were linked to lung cancer risk in Asian populations. Odds ratios (OR) and 95 % confidence intervals (95 % CI) were estimated using unconditional logistic regression.Frequent consumption of fermented vegetables was associated with increased NPC risk (OR of consumption ≥weekly vs. ≤rare 1.78, 95 % CI 1.24–2.55, p trend = 0.005), as was tobacco smoking (p trend < 0.001), former and current smokers displaying OR of 1.57 (95 % CI 1.10–2.30) and 2.00 (95 % CI 1.48–2.71) compared to never smokers, respectively. Four out of six genetic variants implicated in the recent NPC GWAS were associated with NPC risk (p trend ≤ 0.03), as well as two variants (rs402710 and rs2736098) on the TERT locus at 5p15.33 (p = 0.004 and p = 0.04, respectively).These results strengthen our previous observation that tobacco smoking is an important risk factor of NPC in this population. Four out of six genetic variants identified in a recent NPC GWAS were confirmed, and the association noted with variants on 5p15.33 suggests that this locus is involved in NPC susceptibility, representing a novel finding in NPC epidemiology.
Starting Page	1995
Ending Page	2002
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	23
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nasopharyngeal carcinoma (NPC) Thailand Tobacco smoking Genetic Genotyping Biomedicine general Epidemiology Cancer Research Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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