NDLI: Case–control analysis on metformin and cancer of the esophagus

Content Provider	Springer Nature Link
Author	Becker, Claudia Meier, Christoph R. Jick, Susan S. Bodmer, Michael
Copyright Year	2013
Abstract	Metformin use has been associated with decreased cancer risks, though data on esophageal cancer are scarce. We explored the relation between use of metformin or other anti-diabetic drugs and the risk of esophageal cancer.We conducted a case–control analysis in the UK-based general practice research database (GPRD, now clinical practice research datalink, CPRD). Cases were individuals with an incident diagnosis of esophageal cancer between 1994 and 2010 at age 40–89 years. Ten controls per case were matched on age, sex, calendar time, general practice, and number of years of active history in the GPRD prior to the index date. Various potential confounders including diabetes mellitus, gastro-esophageal reflux, and use of proton-pump inhibitors were evaluated in univariate models, and the final results were adjusted for BMI and smoking. Results are presented as odds ratios (ORs) with 95 % confidence intervals (CI).Long-term use (≥30 prescriptions) of metformin was not associated with a materially altered risk of esophageal cancer (adj. OR 1.23, 95 % CI 0.92–1.65), nor was long-term use of sulfonylureas (adj. OR 0.93, 95 % CI 0.70–1.23), insulin (adj. OR 0.87, 95 % CI 0.60–1.25), or of thiazolidinediones (adj. OR 0.71, 95 % CI 0.37–1.36).In our population-based study, use of metformin was not associated with an altered risk of esophageal cancer.
Starting Page	1763
Ending Page	1770
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	24
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-07-03
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Esophageal cancer Anti-diabetic drugs Epidemiology Case–control analysis Metformin Cancer Research Biomedicine general Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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