NDLI: Metabolic syndrome and esophageal and gastric cancer

Content Provider	Springer Nature Link
Author	Lin, Yulan Ness Jensen, Eivind Hveem, Kristian Lagergren, Jesper Lu, Yunxia
Copyright Year	2015
Abstract	The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear.This was a large nationwide cohort study based on data from 11 prospective population-based cohorts in Norway with long-term follow-up, the Cohort of Norway (CONOR) and the third Nord-Trøndelag Health Study (HUNT3). The metabolic syndrome was assessed by objective anthropometric and metabolic biochemical measures and was defined by the presence of at least three of the following five factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension and high glucose. Newly diagnosed cases of esophageal adenocarcinoma, esophageal squamous-cell carcinoma and gastric adenocarcinoma were identified from the Norwegian Cancer Registry. Hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox proportional hazard models with adjustment for potential confounders.Among 192,903 participants followed up for an average of 10.6 years, 62 developed esophageal adenocarcinoma, 64 had esophageal squamous-cell carcinoma and 373 had gastric adenocarcinoma. The metabolic syndrome was significantly associated with an increased risk of gastric adenocarcinoma (HR 1.44, 95 % CI 1.14–1.82), but not associated with esophageal adenocarcinoma (HR 1.32, 95 % CI 0.77–2.26) or esophageal squamous-cell carcinoma (HR 1.08, 95 % CI 0.64–1.83). Increased waist circumference was associated with an increased HR of esophageal adenocarcinoma (HR 2.48, 95 % CI 1.27–4.85). No significant association was found between any single component of the metabolic syndrome and risk of esophageal squamous-cell carcinoma. High waist circumference (HR 1.71, 95 % CI 1.05–2.80), hypertension (HR 2.41, 95 % CI 1.44–4.03) and non-fasting glucose (HR 1.74, 95 % CI 1.18–2.56) were also related to an increased risk of gastric adenocarcinoma in women, but not in men.Metabolic syndrome was associated with an increased risk of gastric adenocarcinoma in women. Of the individual components of the metabolic syndrome, high waist circumference was positively associated with risk of esophageal adenocarcinoma. Positive associations were also observed for women between high waist circumference, hypertension, high non-fasting glucose and risk of gastric adenocarcinoma. However, further evidence is warranted due to the limited number of cases and the inability to effectively identify gastric cardia adenocarcinoma.
Starting Page	1825
Ending Page	1834
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-10-08
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Serum lipid Metabolic syndrome Hypertension Neoplasm Esophagus Stomach Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Fiber intake and risk of adenocarcinomas of the esophagus and stomach

Association of colorectal adenoma with components of metabolic syndrome

Cancers of the esophagus and carbonated beverage consumption: a population-based case–control study

Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)

Cigarette smoking and the risk of Barrett’s esophagus

Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas

Iron intake and markers of iron status and risk of Barrett’s esophagus and esophageal adenocarcinoma

Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction

Jasmine tea consumption and upper gastrointestinal cancer in China

Metabolic syndrome and esophageal and gastric cancer

Similar Documents

Fiber intake and risk of adenocarcinomas of the esophagus and stomach

Association of colorectal adenoma with components of metabolic syndrome

Cancers of the esophagus and carbonated beverage consumption: a population-based case–control study

Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)

Cigarette smoking and the risk of Barrett’s esophagus

Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas

Iron intake and markers of iron status and risk of Barrett’s esophagus and esophageal adenocarcinoma

Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction

Jasmine tea consumption and upper gastrointestinal cancer in China

Metabolic syndrome and esophageal and gastric cancer