NDLI: Metformin and prostate cancer mortality: a meta-analysis

Content Provider	Springer Nature Link
Author	Stopsack, Konrad H. Ziehr, David R. Rider, Jennifer R. Giovannucci, Edward L.
Copyright Year	2015
Abstract	Observational studies report conflicting results on the association between metformin exposure and prostate cancer outcomes. This meta-analysis summarizes studies reporting overall survival, prostate cancer-specific mortality, and biochemical recurrence.PubMed and Embase were systematically reviewed to identify studies investigating the association between metformin use and clinical endpoints among men with prostate cancer while taking confounding by diabetes diagnosis into account. Pooled risk estimates (hazard ratios, HRs) and 95 % confidence intervals (CIs) were calculated using random-effects models. Sensitivity analyses for quality components and factors for heterogeneity were conducted.Of 549 articles identified, nine retrospective cohort studies representing 9,186 patients were included. There was significant heterogeneity between studies, and studies differed in quality. Metformin use was associated with improved overall survival in studies with clear risk window definition (HR 0.88, 95 % CI 0.86–0.90, p < 0.001) and in studies with potential immortal time bias (HR 0.52, 95 % CI 0.41–0.65, p < 0.001). No significant association with prostate cancer-specific mortality was detected (HR 0.76, 95 % CI 0.44–1.31, p = 0.33). Metformin use was associated with a decreased risk of biochemical recurrence (HR 0.79, 95 % CI 0.63–1.00, p = 0.047).This meta-analysis suggests a benefit of metformin in men with diabetes and prostate cancer. However, further carefully designed studies are needed to confirm findings and to assess potential generalization to non-diabetic, non-white, and less aggressively treated men with prostate cancer.
Starting Page	105
Ending Page	113
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	27
Issue Number	1
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-11-04
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prostate cancer Diabetes mellitus Metformin Mortality Biochemical recurrence Meta-analysis Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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