NDLI: A generic label-free microfluidic microobject sorter using a magnetic elastic diverter

Content Provider	Springer Nature Link
Author	Zhang, Jiachen Onaizah, Onaizah Sadri, Amir Diller, Eric
Copyright Year	2017
Abstract	Cell sorters play important roles in biological and medical applications, such as cellular behavior study and disease diagnosis and therapy. This work presents a label-free microfluidic sorter that has a downstream-pointing magnetic elastic diverter. Different with most existing magnetic sorters, the proposed device does not require the target microobjects to be intrinsically magnetic or coated with magnetic particles, giving users more flexibility in sorting criteria. The diverter is wirelessly deformed by an applied magnetic field, and its deformation induces a fluid vortex that sorts incoming microobjects, e.g., cells, to the collection outlet. The diverter does not touch samples in this process, reducing the sample contamination and damage risks. This sorter uses a magnetic field generated by off-chip electromagnetic coils that are centimeters away from the device. With simple structure and no on-chip circuits or coils, this device can be integrated with other lab-on-a-chip instruments in a sealed chip, ameliorating the safety concerns in handling hazardous samples. The parallel and independent control of two such diverters on a single chip were demonstrated, showing the potential of doubling the overall throughput or forming a two-stage cascaded sorter. The sorter was modeled based on the Euler-Bernoulli beam theory and its reliability was demonstrated by achieving a raw success rate of 96.68% in sorting 1506 registered microbeads. With a simple structure, the sorter is easy and cheap to fabricate. The advantages of the proposed sorter make it a promising multi-purpose sorting tool in both academic and industrial applications.
Starting Page	1
Ending Page	13
Page Count	13
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	19
Issue Number	2
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2017-05-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidic cell sorter Magnetic actuation Mechanical sorting Magnetic elastic composite Lab-on-a-chip Biomedical Engineering Biological and Medical Physics, Biophysics Nanotechnology Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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