NDLI: Clinical and Morphological Characteristics of Chorioretinal Degeneration in Early Aging OXYS Rats

Content Provider	Springer Nature Link
Author	Zhdankina, A. A. Fursova, A. Zh. Logviv, S. V. Kolosova, N. G.
Copyright Year	2008
Abstract	OXYS rats are characterized by early development of cataract and chorioretinal degeneration with clinical manifestations similar to those observed in senile cataract and ageassociated macular degeneration in humans. According to fundoscopy findings, the incidence of chorioretinal degeneration sharply increases in OXYS rats by the age of 4.5 months, when all animals develop signs of fundus oculi pathology. Morphological analysis of semithin sections of the posterior wall of the eye in OXYS rats aged 5 months showed that choroid vessels, pigmented epithelium, and radial glia were most vulnerable to injury. Retinal hypoxia and destruction of the pigmented epithelium associated with circulatory disorders in the choroid vessels presumably lead to injuries of the neurosensory cells (mainly the external segments) and a 3.5-fold increase in the percent of photoreceptors with nuclear pyknosis in comparison with the control. These results indicate that OXYS rats represent an adequate model of age-associated macular degeneration and can be used for studies of the pathogenesis of this condition and development of methods for its treatment and prevention.
Starting Page	455
Ending Page	458
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	146
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2009-02-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	chorioretinal degeneration OXYS rats age-associated macular degeneration Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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