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| Content Provider | Springer Nature Link |
|---|---|
| Author | Skurikhin, E. G. Pershina, O. V. Minakova, M. Yu. Ermakova, N. N. Firsova, T. V. Dygai, A. M. Gol’dberg, E. D. |
| Copyright Year | 2008 |
| Abstract | The role of central adrenergic structures in the regulation of the erythroid hematopoietic stem was studied during administration of cyclophosphamide and 5-fluorouracil. The central nervous system contributed to suppression of erythropoiesis during cytostatic treatment. The suppressive effect of brain adrenergic structures on the erythron after treatment with cyclophosphamide and 5-fluorouracil was related to dysfunction of adherent cells in the hemopoiesis-inducing microenvironment (formation of hemopoietic islets and secretion of erythropoietic activity) and production of growth factors by myelokaryocytes, respectively. Brain norepinephrine had an inhibitory effect on proliferative activity and differentiation of erythroid precursors that were associated with the erythropoietin and peripheral α-adrenergic structures. However, stimulation of β-adrenergic structures was followed by an increase in the rate of erythroid cell maturation. |
| Starting Page | 405 |
| Ending Page | 410 |
| Page Count | 6 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 146 |
| Issue Number | 4 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-02-10 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | adrenergic system precursors hemopoiesis-inducing microenvironment erythropoiesis cytostatics Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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