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  1. Bulletin of Experimental Biology and Medicine
  2. Bulletin of Experimental Biology and Medicine : Volume 146
  3. Bulletin of Experimental Biology and Medicine : Volume 146, Issue 4, October 2008
  4. Drug Modulation of Transductor Function of Na+,K+-ATPase
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Bulletin of Experimental Biology and Medicine : Volume 162
Bulletin of Experimental Biology and Medicine : Volume 161
Bulletin of Experimental Biology and Medicine : Volume 160
Bulletin of Experimental Biology and Medicine : Volume 159
Bulletin of Experimental Biology and Medicine : Volume 158
Bulletin of Experimental Biology and Medicine : Volume 157
Bulletin of Experimental Biology and Medicine : Volume 156
Bulletin of Experimental Biology and Medicine : Volume 155
Bulletin of Experimental Biology and Medicine : Volume 154
Bulletin of Experimental Biology and Medicine : Volume 153
Bulletin of Experimental Biology and Medicine : Volume 152
Bulletin of Experimental Biology and Medicine : Volume 151
Bulletin of Experimental Biology and Medicine : Volume 150
Bulletin of Experimental Biology and Medicine : Volume 149
Bulletin of Experimental Biology and Medicine : Volume 148
Bulletin of Experimental Biology and Medicine : Volume 147
Bulletin of Experimental Biology and Medicine : Volume 146
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 6, December 2008
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 5, November 2008
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 4, October 2008
Transgeneration Effects of Antenatal Acute Hypoxia during Early Organogenesis
Permanent Modification of Neurohormone Expression in the Hypothalamus of Rats on the Model of Learned Helplessness
Role of Nitric Oxide in Prevention of Cognitive Disorders in Neurodegenerative Brain Injuries in Rats
In Vivo Effect of Selective Macrophage Suppression on the Development of Intrahepatic Cholestasis in Mice
Changes in Phospholipid Composition of Synaptic Membranes in Frontal Lobes of Cerebral Hemispheres in Cats at Various Stages of Hemorrhagic Shock
Adrenergic Regulation of Erythropoiesis during Cytostatic-Induced Myelosuppressions
Specific Response of the Organism and Blood Leukocytes in Rats of Different Genetic Strains to Hypoxia
Stereotypes of Structural Modification of the Urothelium in Various Diseases of the Urinary Bladder and Prostate
Study of Polymorphic Variants C190T, G191A, G857A, and 859Del of the NAT2 Gene by the Method of Restriction Fragment Length Polymorphism
Variations in Functional Activity of the Hormone-Sensitive Adenylate Cyclase System in Tissues of Gastropod Mollusks with Streptozotocin-Induced Diabetes
The Stage of Offspring of Female Rats after Treatment with Cytostatics of Various Groups
Hypothermic Effect of 5-HT1A Receptor Agonist: Comparison of Intranasal, Intraperitoneal, and Subcutaneous Routes of Administration
Drug Modulation of Transductor Function of Na+,K+-ATPase
Mechanisms of Penicillin Antibiotic Interactions with Human Erythrocytes
Immune Reactions in the Progeny of Female Rats Treated with Paclitaxel
Evaluation of the Effect of β-Endorphin on IL-4 and γ-IFN Production by CD4+ Lymphocytes
Immunoliposomal Containers as Systems of Directed Transport of Minor Interfering RNA into Schwann Cells
Clinical and Morphological Characteristics of Chorioretinal Degeneration in Early Aging OXYS Rats
Correlations of Arterial Hemodynamics with the Severity of Clinical Manifestations of Vertebrobasilar Insufficiency
Relationship between the Degree of Cardiovascular Adaptation and Th1/Th2 Polarization of Immune Response
Analysis of Major Isoforms of Human Growth Hormone before and after Intensive Physical Exercise
Ultrastructure of Myocardial Capillary Endothelium in Children with Congenital Heart Disease
Comparative Analysis of Acupuncture Effects on Amino Containing Structures of the Rat Skin in Some Acupuncture Points
Structural Modifications of Colonic Transplant in Plastic Repair of the Esophagus
Heterokaryon Formation as a Method for Neuron Regeneration in Postischemic Injury to Cerebral Cortex in Rats
Exercise Tests and BBB Method for Evaluation of Motor Disorders in Rats after Contusion Spinal Injury
Method for Detecting Quantitative Differences in the Parameters of Involuntary Effort Fluctuations in Healthy Volunteers and Patients with Parkinson’s Syndrome
Injection Form of Tissue-Engineering Construct on the Basis of Autogenous Chondroblasts for Regeneration of the Cartilaginous Tissue
Heterogeneity of Mitochondrial Potential as a Marker for Isolation of Pure Cardiomyoblast Population
Multipotent Mesenchymal Stromal Cells of Autologous Bone Marrow Stimulate Neoangiogenesis, Restore Microcirculation, and Promote Healing of Indolent Ulcers of the Stomach
Effect of Xenotransplantation of Cell Cultures Enriched with Stem and Progenitor Cells on Hormonal Profile of Rats with Abdominal Cryptorchism
Clinical Study of the Efficiency of Combined Cell Transplant on the Basis of Multipotent Mesenchymal Stromal Adipose Tissue Cells in Patients with Pronounced Deficit of the Maxillary and Mandibulary Bone Tissue
New Molecular Systems. Peculiarities of Structural Organization of Biopolymers
Viral Vectors for Stable Transduction of Human Mesenchymal Stem Cells: Systems Based on Adeno-Associated Viruses and Lentiviruses
A New Approach to Evaluation of Osteogenic Potential of Mesenchymal Stromal Cells
Role of Cyclooxygenases in the Stimulatory Effect of Carcinogen 1,2-Dimethylhydrazine on Stem Cell Survival in the Intestinal Epithelium and Bone Marrow
Mechanisms of Therapeutic Effects of Granulocytic Colony-Stimulating Factor in Experimental Diabetes Mellitus
Comparative Analysis of Reproduction of Influenza Virus Strains in Cell Lines Perspective for the Creation of Cultural Vaccines Grown on Nutrient Medium on the Basis of Rise Flour Protein Hydrolysate
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 3, September 2008
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 2, August 2008
Bulletin of Experimental Biology and Medicine : Volume 146, Issue 1, July 2008
Bulletin of Experimental Biology and Medicine : Volume 145
Bulletin of Experimental Biology and Medicine : Volume 144
Bulletin of Experimental Biology and Medicine : Volume 143
Bulletin of Experimental Biology and Medicine : Volume 142
Bulletin of Experimental Biology and Medicine : Volume 141
Bulletin of Experimental Biology and Medicine : Volume 140
Bulletin of Experimental Biology and Medicine : Volume 139
Bulletin of Experimental Biology and Medicine : Volume 138
Bulletin of Experimental Biology and Medicine : Volume 137
Bulletin of Experimental Biology and Medicine : Volume 136
Bulletin of Experimental Biology and Medicine : Volume 135
Bulletin of Experimental Biology and Medicine : Volume 134
Bulletin of Experimental Biology and Medicine : Volume 133
Bulletin of Experimental Biology and Medicine : Volume 132
Bulletin of Experimental Biology and Medicine : Volume 131
Bulletin of Experimental Biology and Medicine : Volume 130
Bulletin of Experimental Biology and Medicine : Volume 129
Bulletin of Experimental Biology and Medicine : Volume 128
Bulletin of Experimental Biology and Medicine : Volume 127
Bulletin of Experimental Biology and Medicine : Volume 126
Bulletin of Experimental Biology and Medicine : Volume 125
Bulletin of Experimental Biology and Medicine : Volume 124
Bulletin of Experimental Biology and Medicine : Volume 123

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Drug Modulation of Transductor Function of Na+,K+-ATPase

Content Provider Springer Nature Link
Author Lopatina, E. V. Pennyaynen, V. A. Rogachevskyi, I. V. Krylov, B. V.
Copyright Year 2008
Abstract Experimental proof of the hypothesis on modulation of the transductor function of Na+,K+-ATPase by the ouabain—Ca2+ chelate complex was obtained by the method organotypic tissue culture. Quantum chemical estimations detected two principally different modes of Ca2+ ion chelation by ouabain molecule. It is hypothesized that the ouabain—Ca2+—Na+,K+-ATPase ligand-receptor complex is formed due to ion-ion bonds. The formation of the complex serves as the signal triggering the enzyme transductor function. It is experimentally proven that ouabain is incapable of inhibiting neurite growth in sensory neuron and heart tissue explants after removal of free calcium from the nutrient medium with EGTA.
Starting Page 436
Ending Page 438
Page Count 3
File Format PDF
ISSN 00074888
Journal Bulletin of Experimental Biology and Medicine
Volume Number 146
Issue Number 4
e-ISSN 15738221
Language English
Publisher Springer US
Publisher Date 2009-02-11
Publisher Place Boston
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword organotypical tissue culture ouabain EGTA Na+,K+-ATPase signal transductor quantum-chemical estimations Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type Text
Resource Type Article
Subject Medicine Biochemistry, Genetics and Molecular Biology
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