NDLI: Image Registration Demonstrates the Growth Plate has a Variable Affect on Vertebral Strain

Content Provider	Springer Nature Link
Author	Hardisty, M. R. Akens, M. Yee, A. J. Whyne, C. M.
Copyright Year	2010
Abstract	Characterizing the biomechanical behavior of the vertebrae is important in understanding the impact of structural and material changes on spinal growth and fracture risk. The growth plate is critical for the normal development of the skeleton, with abnormalities leading to uneven maturation. Little is known about how growth plates affect the stress and strain experienced by the surrounding bone. Concentrated strain within the growth plate may influence mechanical cell signaling during development, lead to increased fracture risk at this site and may influence average bone strain measures. It is hypothesized that the growth plates and adjacent bony areas will take up a large amount of the strain within rat-tail vertebrae under axial compressive loading, leading to increased average bone strain measures. The sixth caudal vertebrae of 8 rnu/rnu rats were μCT scanned in both loaded (20–32 N axial compression) and unloaded configurations. Image registration was used to calculate strain in the bone due to the applied load by finding a spatial mapping between the two scans. In seven of the eight rats, the majority of the strain measured within their vertebrae was concentrated in the growth plates. Five of the specimens had growth plates that demonstrated rigid behavior in contrast to compliant growth plate behavior seen in the other three rats. The presence of a compliant growth plate led to higher average (−0.03 vs. −0.01) and maximum (−0.13 vs. −0.02) strains. The strain within the growth plate is important to consider when interpreting apparent tissue level biomechanical data commonly reported in the literature as this study suggests strains are not uniformly distributed with high concentrations in and around the growth plate. This strain distribution may provide insight into the mechanical signals that cells experience during the formation of new bone, with the higher strains near the growth plate signaling cells to lay down more bone, while also leading to increased risk of fracture in this region.
Starting Page	2948
Ending Page	2955
Page Count	8
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	9
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-05-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Growth plate Biomechanics Digital image correlation Spine Vertebrae Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Non-Destructive Evaluation of the Effects of Combined Bisphosphonate and Photodynamic Therapy on Bone Strain in Metastatic Vertebrae Using Image Registration

Marker-Free Tracking of Facet Capsule Motion Using Polarization-Sensitive Optical Coherence Tomography

Symmetric Biomechanically Guided Prone-to-Supine Breast Image Registration

Noninvasive Determination of Ligament Strain with Deformable Image Registration

Viscoelastic Properties of Human Tympanic Membrane

Soft Tissue Phantoms for Realistic Needle Insertion: A Comparative Study

A Measure for Characterizing Sliding on Lung Boundaries

Hierarchical CT to Ultrasound Registration of the Lumbar Spine: A Comparison with Other Registration Methods

Geometry of the Intervertebral Volume and Vertebral Endplates of the Human Spine

Image Registration Demonstrates the Growth Plate has a Variable Affect on Vertebral Strain

Similar Documents

Non-Destructive Evaluation of the Effects of Combined Bisphosphonate and Photodynamic Therapy on Bone Strain in Metastatic Vertebrae Using Image Registration

Marker-Free Tracking of Facet Capsule Motion Using Polarization-Sensitive Optical Coherence Tomography

Symmetric Biomechanically Guided Prone-to-Supine Breast Image Registration

Noninvasive Determination of Ligament Strain with Deformable Image Registration

Viscoelastic Properties of Human Tympanic Membrane

Soft Tissue Phantoms for Realistic Needle Insertion: A Comparative Study

A Measure for Characterizing Sliding on Lung Boundaries

Hierarchical CT to Ultrasound Registration of the Lumbar Spine: A Comparison with Other Registration Methods

Geometry of the Intervertebral Volume and Vertebral Endplates of the Human Spine

Image Registration Demonstrates the Growth Plate has a Variable Affect on Vertebral Strain