NDLI: Nanomechanics of Multiple Units in the Erythrocyte Membrane Skeletal Network

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Nanomechanics of Multiple Units in the Erythrocyte Membrane Skeletal Network

Content Provider	Springer Nature Link
Author	Oliveira, Mauricio Vera, Carlos Valdez, Pierre Sharma, Yasha Skelton, Robert Sung, Lanping Amy
Copyright Year	2010
Abstract	Erythrocytes undergo deformations when they transport O2 and CO2 across the membrane, yet the 3D nanomechanics of the skeletal network remains poorly understood. Expanding from our previous single isolated unit, we now simulate networks consisting of 1–10 concentric rings of repeating units in equibiaxial deformation. The networks are organized with (1) a 3D model for a single unit, (2) a wrap-around mode between Sp and actin protofilament in the intra-unit interaction, and (3) a random inter-unit connectivity. These assumptions permit efficient five-degrees-of-freedom (5DOF) simulations when up to 30 pN of radial forces are applied to the boundary spectrin (Sp) and the center and other units are analyzed. As 6 Sp balance their tensions, hexagonal units become irregular. While actin protofilaments remain tangent to the network, their yaw (Φ) angles change drastically with addition of neighboring units or an Sp unfolding. It is anticipated that during deformation, transmembrane complexes associated with the network move laterally through the lipid bilayer and increase the diffusion of molecules across the membrane. When protofilament/Sp sweeps under the lipid bilayer, they mix up the submembrane concentration gradient. Thus, the nanomechanics of actin protofilaments and Sp may enhance the transport of molecules during erythrocyte deformation.
Starting Page	2956
Ending Page	2967
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	9
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-05-20
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Actin protofilament Red blood cell Spectrin Junctional complex Microcirculation Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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