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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jaatinen, L. Salemi, S. Miettinen, S. Hyttinen, J. Eberli, D. |
| Copyright Year | 2014 |
| Abstract | Damage to the nervous system can be caused by several types of insults, and it always has a great effect on the life of an individual. Due to the limited availability of neural transplants, alternative approaches for neural regeneration must be developed. Stem cells have a great potential to support neuronal regeneration. Human adipose-derived stem cells (hADSCs) have gained increasing interest in the fields of regenerative medicine due to their multilineage potential and easy harvest compared to other stem cells. In this study, we present a growth factor-free method for the differentiation of hADSCs toward neuron-like cells. We investigated the effect of electric current and copper on neuronal differentiation. We analyzed the morphological changes, the mRNA and protein expression levels in the stimulated cells and showed that the combination of current and copper induces stem cell differentiation toward the neuronal lineage with elongation of the cells and the upregulation of neuron-specific genes and proteins. The induction of the neuronal differentiation of hADSCs by electric field and copper may offer a novel approach for stem cell differentiation and may be a useful tool for safe stem cell-based therapeutic applications. |
| Starting Page | 1014 |
| Ending Page | 1023 |
| Page Count | 10 |
| File Format | |
| ISSN | 00906964 |
| Journal | Annals of Biomedical Engineering |
| Volume Number | 43 |
| Issue Number | 4 |
| e-ISSN | 15739686 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-10-07 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Adipose-derived stem cell Electric current Copper Differentiation Neurons Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering |
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