NDLI: Novel Method to Track Soft Tissue Deformation by Micro-Computed Tomography: Application to the Mitral Valve

Content Provider	Springer Nature Link
Author	Pierce, Eric L. Bloodworth, Charles H. Naran, Ajay Easley, Thomas F. Jensen, Morten O. Yoganathan, Ajit P.
Copyright Year	2015
Abstract	Increasing availability of micro-computed tomography (µCT) as a structural imaging gold-standard is bringing unprecedented geometric detail to soft tissue modeling. However, the utility of these advances is severely hindered without analogous enhancement to the associated kinematic detail. To this end, labeling and following discrete points on a tissue across various deformation states is a well-established approach. Still, existing techniques suffer limitations when applied to complex geometries and large deformations and strains. Therefore, we herein developed a non-destructive system for applying fiducial markers (minimum diameter: 500 µm) to soft tissue and tracking them through multiple loading conditions by µCT. Using a novel applicator to minimize adhesive usage, four distinct marker materials were resolvable from both tissue and one another, without image artifacts. No impact on tissue stiffness was observed. µCT addressed accuracy limitations of stereophotogrammetry (inter-method positional error 1.2 ± 0.3 mm, given marker diameter 1.9 ± 0.1 mm). Marker application to ovine mitral valves revealed leaflet Almansi areal strains (45 ± 4%) closely matching literature values, and provided radiographic access to previously inaccessible regions, such as the leaflet coaptation zone. This system may meaningfully support mechanical characterization of numerous tissues or biomaterials, as well as tissue-device interaction studies for regulatory standards purposes.
Starting Page	2273
Ending Page	2281
Page Count	9
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	44
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-11-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ex vivo Material properties Simulation Cardiovascular Imaging Micro-computed tomography Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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