NDLI: Finite Element Modeling of Mitral Valve Dynamic Deformation Using Patient-Specific Multi-Slices Computed Tomography Scans

Content Provider	Springer Nature Link
Author	Wang, Qian Sun, Wei
Copyright Year	2012
Abstract	The objective of this study was to develop a patient-specific finite element (FE) model of a human mitral valve. The geometry of the mitral valve was reconstructed from multi-slice computed tomography (MSCT) scans at middle diastole with distinguishable mitral leaflet thickness, chordal origins, chordal insertion points, and papillary muscle locations. Mitral annulus and papillary muscle dynamic motions were also quantified from MSCT scans and prescribed as boundary conditions for the FE simulation. Material properties of the human mitral leaflet tissues were obtained from biaxial tests and characterized by an anisotropic hyperelastic material model. In vivo dynamic closing of the mitral valve was simulated. The closed shape of the mitral valve output from the simulation was similar to the mitral valve geometry reconstructed from MSCT images at middle systole. Forces from the anterolateral and posteromedial papillary muscle groups at middle systole were 4.51 N and 5.17 N, respectively. The average maximum principal stress of the midsection of the anterior mitral leaflet was approximately 160 kPa at the systolic peak. Results demonstrated that the developed FE model could closely replicate in vivo mitral valve dynamic motion during middle diastole and systole. This model may serve as a basis for utilizing computational simulations to obtain a better understanding of mitral valve mechanics, disease and surgical repair.
Starting Page	142
Ending Page	153
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	41
Issue Number	1
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2012-07-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Multi-slice computed tomography Mitral valve Chordae tendineae Finite element simulation Patient-specific Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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