NDLI: Effect of Diet and Age on Arterial Stiffening Due to Atherosclerosis in ApoE−/− Mice

Content Provider	Springer Nature Link
Author	Cilla, M. Pérez, M. M. Peña, E. Martínez, M. A.
Copyright Year	2015
Abstract	This work analyzes the progressive stiffening of the aorta due to atherosclerosis development of both ApoE−/− and C57BL/6J mice fed on a Western (n = 5) and a normal (n = 5) chow diet for the ApoE−/− group and on a normal chow diet (n = 5) for the C57BL/6J group. Sets of 5 animals from the three groups were killed after 10, 20, 30 and 40 weeks on their respective diets (corresponding to 17, 27, 37 and 47 weeks of age). Mechanical properties (inflation test and axial residual stress measurements) and histological properties were compared for both strains, ApoE−/− on the hyper-lipidic diet and both ApoE−/− and C57BL/6J on the normal diet, after the same period and after different periods of diet. The results indicated that the aorta stiffness in the ApoE−/− and C57BL/6J mice under normal diet remained approximately constant irrespective of their age. However, the arterial stiffness in the ApoE−/− on the hyper-lipidic diet increased over time. Statistical differences were found between the group after 10 weeks and the groups after 30 and 40 weeks of a hyper-lipidic diet. Comparing the hyper-lipidic and normal diet mice, statistical differences were also found between both diets in all cases after 40 weeks of diet, frequently after 30 weeks, and in some cases after 20 weeks. The early stages of lesion corresponded to the first 2 weeks of diet. Advanced lesions were found at 30 weeks and, finally, the aorta was completely damaged after 40 weeks of diet. In conclusion, we found substantial changes in the mechanical properties of the aorta walls of the ApoE−/− mice fed with the hyper-lipidic diet compared to the normal chow diet groups for both the ApoE−/− and C57BL/6J groups. These findings could serve as a reference for the study of changes in the arterial wall properties in cases of atherosclerosis.
Starting Page	2202
Ending Page	2217
Page Count	16
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	44
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-10-26
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Atherosclerosis Mechanical properties Stiffness Residual stresses Inflation test Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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