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| Content Provider | Springer Nature Link |
|---|---|
| Author | Grasa, J. Calvo, B. Delgado Andrade, C. Navarro, M. P. |
| Copyright Year | 2012 |
| Abstract | Passive elastic behavior of tendon tissue from rats subjected to different dietary treatments was characterized. For that purpose, twenty-four weanling Wistar rats (41.02 ± 0.16 g) were randomly distributed into four groups. During 88 days each group was fed on different diets: control diet and diets containing advanced glycation end products (AGEs) from glucose–lysine model system, from bread crust and bread dough, respectively. After the trial animals were sacrificed and tendon samples were extracted and tested mechanically to fracture in a uniaxial tensile test machine. A transversely-hyperelastic model was formulated based on stress–strain relationships and its parameters were fit to the experimental data using the Levenberg–Marquardt optimization algorithm. Material parameters were incorporated in a finite element model to study different stress–strain distributions in a muscle-tendon unit. Results show higher strains and stresses in the muscle belly when properties of a stiffer tendon associated with a diet rich in AGEs are included in the model. A real increase in this mechanical response of the tissue could imply possible pain in joint mobility. |
| Starting Page | 488 |
| Ending Page | 496 |
| Page Count | 9 |
| File Format | |
| ISSN | 00906964 |
| Journal | Annals of Biomedical Engineering |
| Volume Number | 41 |
| Issue Number | 3 |
| e-ISSN | 15739686 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-10-13 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Tendon stiffness Maillard reaction products Advanced glycation end products (AGEs) Hyperelastic behaviour Finite element Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering |
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