NDLI: The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice

Content Provider	Springer Nature Link
Author	Christiansen, Blaine A. Silva, Matthew J.
Copyright Year	2006
Abstract	It has been reported that whole-body vibration (WBV) is anabolic to trabecular bone in animal models and humans. It is likely that this anabolic response does not occur uniformly throughout the entire body. Two factors that may affect the observed anabolic response are vibration magnitude and skeletal site of interest. In this study, mice were loaded with WBV of varying magnitudes. After five weeks of loading, bone marrow was flushed from tibias in order to quantify osteoprogenitor cells. Staining with alizarin red (an indicator of mineralization) showed a significant decrease in percent stained area in the 0.3 g loaded group compared to the control group and the 1.0 g group. MicroCT analysis was performed at five skeletal sites: the proximal tibial metaphysis, femoral condyles, distal femoral metaphysis, proximal femur, and L5 vertebral body. Increasing magnitudes of WBV were associated with a non-dose-dependent increase in trabecular bone volume (BV/TV) at the proximal tibial metaphysis, although other sites were unresponsive. There were statistically significant increases in BV/TV in the 0.1 g group (32% increase) and 1.0 g group (43% increase) compared to control (p < 0.05). The 0.1 g and 1.0 g groups also had higher BV/TV than the 0.3 g loaded group. If this non-dose-dependent phenomenon is verified by future studies, it suggests that a range of magnitudes should be examined for each application of WBV.
Starting Page	1149
Ending Page	1156
Page Count	8
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	34
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-06-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Osteoporosis Trabecular bone Mechanical loading Murine MicroCT Osteoprogenitor cells Bone formation Biomedical Engineering Biophysics/Biomedical Physics Mechanics Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

Vertebral Osteoporosis and Trabecular Bone Quality

The Effect of Mechanical Loading on the Metabolism of Growth Plate Chondrocytes

Effects of Loading Orientation on the Morphology of the Predicted Yielded Regions in Trabecular Bone

Whole-body vibration in the skeleton: Development of a resonance-based testing device

The Influence of Center of Rotation on the Assessment of Trabecular Bone Densitometric and Structural Properties

Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotype

Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques

The Effects of Trabecular-Bone Loading Variables on the Surface Signaling Potential for Bone Remodeling and Adaptation

The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice

Similar Documents

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

Vertebral Osteoporosis and Trabecular Bone Quality

The Effect of Mechanical Loading on the Metabolism of Growth Plate Chondrocytes

Effects of Loading Orientation on the Morphology of the Predicted Yielded Regions in Trabecular Bone

Whole-body vibration in the skeleton: Development of a resonance-based testing device

The Influence of Center of Rotation on the Assessment of Trabecular Bone Densitometric and Structural Properties

Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotype

Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques

The Effects of Trabecular-Bone Loading Variables on the Surface Signaling Potential for Bone Remodeling and Adaptation

The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice