NDLI: Statistical Mapping of Speckle Autocorrelation for Visualization of Hyperaemic Responses to Cortical Stimulation

Content Provider	Springer Nature Link
Author	Paul, Joseph S. Al Nashash, Hasan Luft, Andreas R. Le, Thinh M.
Copyright Year	2006
Abstract	Statistically mapped speckle autocorrelation images (SAR) were used to track the hemodynamically active perfusion regions in the rat cortex during and following DC current stimulation with high transverse spatial resolution (38 um). The SAR images provided a spatio-temporal information about the net activation patterns of Cerebral Blood Flow (CBF) changes over a period of time as against those changes for each frame interval estimated using spatial contrasts derived from the first order spatial statistics. Thus the information about the relative maxima of perfusion during a Transient Hyperaemic Episode (THE) across different regions in the imaging window could be identified without the need for actually having to estimate the spatial contrast maps of the imaged region for each frame contained in the time window of observation. With the application of DC stimulation, the regions with a high correlation in the temporal fluctuations were representative of the areas that underwent least changes in activation. By varying the intensity of stimulation, THEs were observed for stimulation current densities in the range 0.1–3.8 mA/mm2 using both the derived speckle contrast maps and concurrently on a Laser Doppler Flow meter, with its probe positioned 1 mm from the site of stimulation. For current densities below the lower threshold of stimulation, the SAR images revealed an unprecedented reduction in the surge amplitude at sites distal to the region of stimulation. This was accompanied by an increase in pixel areas representing minimally active regions of perfusion (“perfusion islets”) with no identifiable peak in the hemodynamic responses estimated from speckle contrast variations. The SAR images can be a useful tool for visualization of slow wave perfusion dynamics during cortical stimulation.
Starting Page	1107
Ending Page	1118
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	34
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-06-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Statistically mapped speckle autocorrelation (SAR) imaging Perfusion THEs Vascular flow Perfusion islets Biomedical Engineering Biophysics/Biomedical Physics Mechanics Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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