NDLI: Microfluidics assisted fabrication of microspheres by poly(2–hydroxyethyl methacrylate)-block-poly(l-histidine) hybrid materials and their utilization as potential drug encapsulants

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Microfluidics assisted fabrication of microspheres by poly(2–hydroxyethyl methacrylate)-block-poly(l-histidine) hybrid materials and their utilization as potential drug encapsulants

Content Provider	Springer Nature Link
Author	Johnson, Renjith P. Choi, Eunji Lee, Kyeong Mi Yu, Seong Jae Chang, Hyuk Chul Suh, Hongsuk Kim, Il
Copyright Year	2012
Abstract	A new series of synthetic polymer bioconjugate hybrid materials consisting of poly(2-hydroxyethyl methacrylate)[p(HEMA)]as a synthetic polymer block and poly(l-histidine) [p(His)] as a polypeptide block were synthesized by combining atom transfer radical polymerization of HEMA with ring opening polymerization of benzyl-N-carboxy-l-histidine anhydride. The resulting biocompatible p(HEMA)25-b-p(His)n (n = 15, 25, 35, and 45) hybrid polymers were investigated for their use as pH-sensitive drug delivery system. Highly uniform microspheres were fabricated by using the microfluidics assisted self-assembly of these block polymers and utilized them as carriers for a chemotherapeutic agent doxorubicin and a beta-lactam antibiotic ampicillin for the evaluation of the drug-loading and release behaviors according to pH, demonstrating the release is sensitive to pH. The capability of the new p(HEMA)-b-p(His) hybrid materials to self-assemble in microenvironments and to effectively encapsulate drug molecules serves as suitable carriers for the delivery of drug molecules with varying physiochemical properties.
Starting Page	257
Ending Page	263
Page Count	7
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	14
Issue Number	1-2
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bioconjugation Drug delivery Microfluidics Polymeric microspheres Self-assembly Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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