NDLI: Synthesis of poly(2-hydroxyethyl methacrylate)-grafted poly(aminoamide) dendrimers as polymeric nanostructures

Content Provider	Springer Nature Link
Author	Banaei, Masoud Salami Kalajahi, Mehdi
Copyright Year	2015
Abstract	Fourth-generation poly(aminoamide) (PAMAM) dendrimer was synthesized via a divergent method with iterative sequence Michael addition or alkylation and amidation reactions with ethylenediamine as primary core and methyl acrylate. Then, its peripheral primary amine groups were conjugated with S-(thiobenzoyl)thioglycolic acid as reversible addition-fragmentation chain transfer (RAFT) agent and poly(2-hydroxyethyl methacrylate) (P(HEMA)) was grafted onto surface via RAFT polymerization. Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H NMR), and dynamic light scattering (DLS) were used to approve the successful synthesis of different nanostructures. Then, fourth-generation, RAFT-conjugated fourth-generation, and P(HEMA)-grafted fourth-generation PAMAM dendrimers were examined as stimuli-responsive nanostructures. Finally, in vitro cellular cytotoxicity was applied to evaluate the biocompatibility of synthesized dendrimers and investigate the cytotoxic effect of grafted polymer using HeLa cells. As a results, fourth-generation and RAFT-conjugated fourth-generation samples showed no stimuli-responsive behavior while P(HEMA)-grafted fourth-generation PAMAM dendrimer had a LCST of 26 °C. Also, fourth-generation and RAFT-conjugated fourth-generation samples were characterized as toxic compounds while grafting P(HEMA) decreased cytotoxicity significantly.
Starting Page	1553
Ending Page	1559
Page Count	7
File Format	PDF
ISSN	0303402X
Journal	Colloid and Polymer Science
Volume Number	293
Issue Number	5
e-ISSN	14351536
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-03-15
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Poly(2-hydroxyethyl methacrylate) RAFT polymerization Dendrimer Thermoresponsive behavior Cytotoxicity Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry Food Science Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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