NDLI: Coupled acoustic-shell model for experimental study of cell stiffness under acoustophoresis

Content Provider	Springer Nature Link
Author	Wijaya, Felix Bob Mohapatra, Abhishek Ray Sepehrirahnama, Shahrokh Lim, Kian Meng
Copyright Year	2016
Abstract	Under the influence of acoustic radiation force, particles can be trapped and deformed at the pressure node in a microfluidic channel. Based on this principle, the elastic modulus of biological cells can be estimated. In this study, a numerical framework, consisting of a boundary element model for acoustic field and an axisymmetric shell model, is developed to simulate the cell deformation under acoustic radiation force. The boundary element model is used to calculate the radiation traction exerted on the cell surface. The cell membrane deformation due to this traction is simulated by using the axisymmetric shell model. The Young’s moduli of algae and red blood cell membranes are then estimated by comparing the experimental observation with the simulated membrane deformation. It is found that the value of Young’s modulus of the red blood cell membrane is lower than that of algae cell membrane. Furthermore, for both cells, the estimated Young’s moduli are negligible compared to the bulk moduli of the cells reported in the previous studies.
Starting Page	1
Ending Page	15
Page Count	15
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	5
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-15
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell membrane deformation Cell membrane stiffness Acoustic radiation force Boundary element method Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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