NDLI: Inertial effects on cylindrical particle migration in linear shear flow near a wall

Content Provider	Springer Nature Link
Author	Kim, Dae Kyung Hyun, Ji Yeon Kim, Sung Chul Kim, Han Sung Lee, Sei Young
Copyright Year	2016
Abstract	Micro-/nanoparticle-based systems are regarded as one of the possible candidates due to the engineerability and multifunctionality to maximize the accumulation of the nano-/microparticle-based drug delivery system on the target. Recent advances in nanotechnology enable the fabrication of diverse particle shapes from simple spherical particles to more complex shapes. The particle dynamics in blood flow and endocytosis characteristics of non-spherical particles change as the non-sphericity effect increases. We used a numerical approach to investigate the particle dynamics in linear shear flow near a wall. We examined the dynamics of slender cylindrical particles with aspect ratio γ = 5.0 in terms of particle trajectory, velocity, and force variation for different Stokes numbers over time. We identified the rotating inertia of particle near a wall as the source of inertial migration toward the wall. The drift velocity of slender cylindrical particles is comparable to that of discoidal particles. We discuss the possibilities and limitations of using slender cylindrical particles as a drug delivery system.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	5
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-30
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Particle-based carriers Cylindrical particle Aspect ratio Linear shear flow Mathematical modeling Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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