NDLI: High-Performance Liquid Chromatographic Separation of Stereoisomers of β-Amino Acids and a Comparison of Separation Efficiencies on Chirobiotic T and TAG Columns

Content Provider	Springer Nature Link
Author	Árki, A. Tourwé, D. Solymár, M. Fülöp, F. Armstrong, D. W. Péter, A.
Copyright Year	2004
Abstract	Direct and indirect reversed-phase high-performance liquid chromatographic methods were developed for the separation of enantiomers of seventeen unnatural β-amino acids, including several β-3-homo amino acids. The direct separations of the underivatized analytes were performed on chiral stationary phases containing macrocyclic glycopeptide antibiotic teicoplanin (Chirobiotic T column) and teicoplanin aglycone (Chirobiotic TAG column). The indirect method involved pre-column derivatization with two new chiral derivatizing agents, (1S,2S)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate, (S,S)-DANI and (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester, (S)-NIFE. The different methods were compared in systematic chromatographic examinations. The effects of organic modifier, mobile phase composition, pH and flow rate on the separation were investigated.
Starting Page	S43
Ending Page	S54
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	60
Issue Number	1
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2004-02-26
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromotography β-Amino acids (1S 2S)-1 3-diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate (S S)-DANI (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester (S)-NIFE Chirobiotic T column Chirobiotic TAG column
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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