NDLI: Seawater requirement for the production of lipoxazolidinones by marine actinomycete strain NPS8920

Content Provider	Springer Nature Link
Author	Sunga, Michelle J. Teisan, Sy Tsueng, Ginger Macherla, Venkat R. Lam, Kin S.
Copyright Year	2008
Abstract	A novel marine actinomycete strain NPS8920 produces a new class of 4-oxazolidinone antibiotics lipoxazolidinone A, B and C. Lipoxazolidinone A possesses good potency (1–2 μg/mL) against drug-resistant pathogens methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). Strain NPS8920 exhibits different morphologies in both agar and submerged cultures. The ability of strain NPS8920 to sporulate on saline-based agar media but not on deionized water-based agar medium supported that strain NPS8920 is a marine actinomycete. While strain NPS8920 does not require seawater for growth, the production of lipoxazolidinones by strain NPS8920 can only be detected in the seawater-based media. The optimal production of lipoxazolidinones was observed in the natural seawater-based medium. Strain NPS8920 produced 10–20% of lipoxazolidinones in the synthetic sea salt Instant Ocean®-based medium and no production in the sodium chloride-based and deionized water-based media.
Starting Page	761
Ending Page	765
Page Count	5
File Format	PDF
ISSN	13675435
Journal	Journal of Industrial Microbiology and Biotechnology
Volume Number	35
Issue Number	7
e-ISSN	14765535
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-04-04
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Lipoxazolidinones Marine actinomycete Antibacterial antibiotic MRSA VRE Microbial Genetics and Genomics Microbiology Bioinformatics Biochemistry Genetic Engineering Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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