NDLI: Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney

Content Provider	Springer Nature Link
Author	Corsetti, Giovanni D’Antona, Giuseppe Ruocco, Chiara Stacchiotti, Alessandra Roma, Claudia Tedesco, Laura Dioguardi, Francesco Rezzani, Rita Nisoli, Enzo
Copyright Year	2014
Abstract	The effects of high-potency statins on renal function are controversial. To address the impact of statins on renal morpho-functional aspects, normotensive young mice were treated with rosuvastatin (Rvs). Moreover, because statins may impair mitochondrial function, mice received either dietary supplementation with an amino acid mixture enriched in essential amino acids (EAAm), which we previously demonstrated to increase mitochondrial biogenesis in muscle or an unsupplemented control diet for 1 month. Mitochondrial biogenesis and function, apoptosis, and insulin signaling pathway events were studied, primarily in cortical proximal tubules. By electron microscopy analysis, mitochondria were more abundant and more heterogeneous in size, with dense granules in the inner matrix, in Rvs- and Rvs plus EAAm-treated animals. Rvs administration increased protein kinase B and endothelial nitric oxide synthase phosphorylation, but the mammalian target of rapamycin signaling pathway was not affected. Rvs increased the expression of sirtuin 1, peroxisome proliferator-activated receptor γ coactivator-1α, cytochrome oxidase type IV, cytochrome c, and mitochondrial biogenesis markers. Levels of glucose-regulated protein 75 (Grp75), B-cell lymphoma 2, and cyclin-dependent kinase inhibitor 1 were increased in cortical proximal tubules, and expression of the endoplasmic reticulum–mitochondrial chaperone Grp78 was decreased. EAAm supplementation maintained or enhanced these changes. Rvs promotes mitochondrial biogenesis, with a probable anti-apoptotic effect. EAAm boosts these processes and may contribute to the efficient control of cellular energetics and survival in the mouse kidney. This suggests that appropriate nutritional interventions may enhance the beneficial actions of Rvs, and could potentially prevent chronic renal side effects.
Starting Page	2189
Ending Page	2203
Page Count	15
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	46
Issue Number	9
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2014-06-13
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Rosuvastatin Essential amino acids Kidney Mitochondria Mice Biochemistry Analytical Chemistry Biochemical Engineering Life Sciences Proteomics Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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