NDLI: Is there a relationship between dietary MSG obesity in animals or humans?

Content Provider	Springer Nature Link
Author	Brosnan, John T. Drewwski, Adam Friedman, Mark I.
Copyright Year	2014
Abstract	The sodium salt of glutamate (monosodium glutamate; MSG) imparts a savory/meaty taste to foods, and has been used as a flavoring agent for millennia. Past research on MSG/glutamate has evaluated its physiologic, metabolic and behavioral actions, and its safety. Ingested MSG has been found to be safe, and to produce no remarkable effects, except on taste. However, some recent epidemiologic and animal studies have associated MSG use with obesity and aberrations in fat metabolism. Reported effects are usually attributed to direct actions of ingested MSG in brain. As these observations conflict with past MSG research findings, a symposium was convened at the 13th International Congress on Amino Acids, Peptides and Proteins to discuss them. The principal conclusions were: (1) the proposed link between MSG intake and weight gain is likely explained by co-varying environmental factors (e.g., diet, physical activity) linked to the “nutrition transition” in developing Asian countries. (2) Controlled intervention studies adding MSG to the diet of animals and humans show no effect on body weight. (3) Hypotheses positing dietary MSG effects on body weight involve results from rodent MSG injection studies that link MSG to actions in brain not applicable to MSG ingestion studies. The fundamental reason is that glutamate is metabolically compartmentalized in the body, and generally does not passively cross biologic membranes. Hence, almost no ingested glutamate/MSG passes from gut into blood, and essentially none transits placenta from maternal to fetal circulation, or crosses the blood–brain barrier. Dietary MSG, therefore, does not gain access to brain. Overall, it appears that normal dietary MSG use is unlikely to influence energy intake, body weight or fat metabolism.
Starting Page	2075
Ending Page	2087
Page Count	13
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	46
Issue Number	9
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2014-06-14
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Monosodium glutamate Glutamic acid Epidemiology Amino acid metabolism Obesity Fat metabolism Biochemistry Analytical Chemistry Biochemical Engineering Life Sciences Proteomics Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?

Taurine prevents fat deposition and ameliorates plasma lipid profile in monosodium glutamate-obese rats

Amino acid sensing in the gastrointestinal tract

Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs

Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?

Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets

Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats

Human splanchnic amino-acid metabolism

Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets

Is there a relationship between dietary MSG obesity in animals or humans?

Similar Documents

Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?

Taurine prevents fat deposition and ameliorates plasma lipid profile in monosodium glutamate-obese rats

Amino acid sensing in the gastrointestinal tract

Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs

Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?

Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets

Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats

Human splanchnic amino-acid metabolism

Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets

Is there a relationship between dietary MSG obesity in animals or humans?