NDLI: Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets

Content Provider	Springer Nature Link
Author	Chen, Gang Zhang, Jun Zhang, Yuzhe Liao, Peng Li, Tiejun Chen, Lixiang Yin, Yulong Wang, Jinquan Wu, Guoyao
Copyright Year	2013
Abstract	This experiment was conducted to investigate the effects of oral administration of monosodium glutamate (MSG) on expression of genes for hepatic lipid and nitrogen metabolism in piglets. A total of 24 newborn pigs were assigned randomly into one of four treatments (n = 6/group). The doses of oral MSG administration, given at 8:00 and 18:00 to sow-reared piglets between 0 and 21 days of age, were 0 (control), 0.06 (low dose), 0.5 (intermediate dose), and 1 (high dose) g/kg body weight/day. At the end of the 3-week treatment, serum concentrations of total protein and high-density lipoprotein cholesterol in the intermediate dose group were elevated than those in the control group (P < 0.05). Hepatic mRNA levels for fatty acid synthase, acetyl-coA carboxylase, insulin-like growth factor-1, glutamate–oxaloacetate transaminase, and glutamate–pyruvate transaminase were higher in the middle-dose group (P < 0.05), compared with the control group. MSG administration did not affect hepatic mRNA levels for hormone-sensitive lipase or carnitine palmitoyl transferase-1. We conclude that oral MSG administration alters hepatic expression of certain genes for lipid and nitrogen metabolism in suckling piglets.
Starting Page	245
Ending Page	250
Page Count	6
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	46
Issue Number	1
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2013-11-13
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Monosodium glutamate Pig Liver Gene expression Biochemistry Analytical Chemistry Biochemical Engineering Life Sciences Proteomics Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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