NDLI: Determination of indometacin and acemetacin in human urine via reduced graphene oxide - based pipette tip solid-phase extraction coupled to HPLC

Content Provider	Springer Nature Link
Author	Yuan, Yanan Sun, Ning Yan, Hongyuan Han, Dandan Row, Kyung Ho
Copyright Year	2015
Abstract	A rapid method for solid-phase extraction (SPE) and quantitation of the non-steroidal anti-inflammatory drugs indometacin and acemetacin in urine was developed. SPE is based in of the use of a reduced graphene oxide (rGO) in a pipette tip, and separation and quantitation is based on HPLC with a Promosil C18 column and UV detection. The amount of sorbent, types and volumes of washing solvent and elution solvent were optimized. The results showed that the use of the rGO sorbent and a miniaturized pipette tip cartridge are distinctly superior to other sorbents including multiwalled carbon nanotubes and conventional SPE cartridges. Linear responses to indometacin and acemetacin are found for the 0.1–50 μg mL−1 concentration ranges, recoveries (at three spiking levels) range from 89.6 % to 95.7 %, and the relative standard deviations are ≤6.4 %. Graphical Abstract A rapid method for solid-phase extraction (SPE) and quantitation of the non-steroidal anti-inflammatory drugs indometacin and acemetacin in urine was developed. SPE is based on the use of reduced graphene oxide (rGO) in a pipette tip, and separation and quantitation is based on HPLC with a Promosil C18 column and UV detection.
Starting Page	799
Ending Page	804
Page Count	6
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	183
Issue Number	2
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2015-12-29
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anti-inflammatory drug Urine analysis Multi-walled carbon nanotubes HLB sorbent Strong cation exchange chromatography SCX Nanomaterial Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

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