NDLI: Fourty years of molecular imprinting in synthetic polymers: origin, features and perspectives

Content Provider	Springer Nature Link
Author	Wulff, Günter
Copyright Year	2013
Abstract	Molecularly imprinted synthetic polymers were discovered 40 years back. They are prepared in the presence of interacting monomers around a molecule that acts as a template. Following polymerization of the monomers together with a large amount of a crosslinker and after removal of the template, an imprint is obtained whose shape and arrangement of functional groups are complementary to the structure of the template (often an analyte). Usually, selective binding of the analyte is observed. These highly cross-linked polymers are also well suitable to engineer enzyme-like activity and specificity. The first part of this review is a personal retrospective description of the first steps into this field. The second part describes recent efforts to develop enzyme models, e.g. for carboxypeptidase A, through the concept of transition state stabilization. It is shown that the introduction of special catalytic moieties such as metal ions leads to a defined orientation of groups inside the active site and, with this, to highly active catalysts. Their activity, efficiency, and proficiency clearly surpass those of other imprinted catalysts and even those of the corresponding catalytic antibodies. A further improvement was accomplished by placing the enzyme-analogue active site inside soluble nanoparticles. A special concept, referred to as “post dilution polymerization method” results in soluble, highly cross-linked, single molecule nanoparticles of controlled molecular weight (~ 39 kDa) having one catalytically active site per particle on average. Figure ᇵ
Starting Page	1359
Ending Page	1370
Page Count	12
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	180
Issue Number	15-16
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2013-05-02
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular imprinting Nanoparticles Michaelis-Menten kinetics Carboxypeptidase A-model Copper-containing catalysts Transmission electron microscopy Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hydrophilic molecularly imprinted polymers for bisphenol A prepared in aqueous solution

Molecular imprinting for anion recognition in aqueous media

Core-shell nanoparticles coated with molecularly imprinted polymers: a review

Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination

Preparation of surface imprinted core-shell particles via a metal chelating strategy: specific recognition of porcine serum albumin

Molecularly imprinted photo-sensitive polyglutamic acid nanoparticles for electrochemical sensing of hemoglobin

Transferrin recognition based on a protein imprinted material prepared by hierarchical imprinting technique

Calcein-functionalized Fe3O4@SiO2 nanoparticles as a reusable fluorescent nanoprobe for copper(II) ion

Surface molecular imprinting for chemiluminescence detection of the organophosphate pesticide chlorpyrifos

Fourty years of molecular imprinting in synthetic polymers: origin, features and perspectives

Similar Documents

Hydrophilic molecularly imprinted polymers for bisphenol A prepared in aqueous solution

Molecular imprinting for anion recognition in aqueous media

Core-shell nanoparticles coated with molecularly imprinted polymers: a review

Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination

Preparation of surface imprinted core-shell particles via a metal chelating strategy: specific recognition of porcine serum albumin

Molecularly imprinted photo-sensitive polyglutamic acid nanoparticles for electrochemical sensing of hemoglobin

Transferrin recognition based on a protein imprinted material prepared by hierarchical imprinting technique

Calcein-functionalized Fe3O4@SiO2 nanoparticles as a reusable fluorescent nanoprobe for copper(II) ion

Surface molecular imprinting for chemiluminescence detection of the organophosphate pesticide chlorpyrifos

Fourty years of molecular imprinting in synthetic polymers: origin, features and perspectives