NDLI: Maternal high-fat diet is associated with altered pancreatic remodelling in mice offspring

Content Provider	Springer Nature Link
Author	Gregorio, Bianca Martins Souza Mello, Vanessa Mandarim de Lacerda, Carlos Alberto Aguila, Marcia Barbosa
Copyright Year	2012
Abstract	To investigate whether a maternal high-fat diet (HF) during pregnancy and/or suckling periods predisposes adult C57BL/6 mice offspring to morphological pancreatic modifications.Male pups were divided into 5 groups: SC (standard chow)—from dams fed SC during gestation and lactation, maintaining an SC diet from postweaning to adulthood; G—from dams fed HF diets during gestation; L—from dams fed HF diets during lactation; GL—from dams fed HF diets during gestation and lactation; and GL/HF—from dams fed HF diets during gestation and lactation, maintaining an HF diet from postweaning to adulthood. We analysed body mass (BM), plasma insulin, pancreas and adipose tissue structures.During the entire experiment, the SC group had the lowest BM. However, GL/HF offspring were heavier than the other groups. This weight gain was also accompanied by adipocyte hypertrophy. At 3 months, G offspring showed an increased insulin levels and impairment in carbohydrates metabolism. Furthermore, pancreatic islets were hypertrophied in G, GL and GL/HF offspring in comparison with SC offspring.HF diet administration during the gestation period is more harmful than during the lactation period, exerting deleterious effects on pancreatic morphology in addition to larger fat deposits in adult mice offspring.
Starting Page	759
Ending Page	769
Page Count	11
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	52
Issue Number	2
e-ISSN	14366215
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-06-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pancreas remodelling Maternal high-fat diet Beta-cell mass Foetal programming Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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