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A maternal high-protein diet predisposes female offspring to increased fat mass in adulthood whereas a prebiotic fibre diet decreases fat mass in rats
| Content Provider | Scilit |
|---|---|
| Author | Hallam, Megan C. Reimer, Raylene A. |
| Copyright Year | 2013 |
| Description | The negative effects of malnourishmentin uterohave been widely explored; the effects of increased maternal macronutrient intake are not known in relation to high fibre, and have been inconclusive with regard to high protein. In the present study, virgin Wistar dams were fed either a control (C), high-protein (40 %, w/w; HP) or high-prebiotic fibre (21·6 %, w/w; HF) diet throughout pregnancy and lactation. Pups consumed the C diet from 3 to 14·5 weeks of age, and then switched to a high-fat/sucrose diet for 8 weeks. A dual-energy X-ray absorptiometry scan and an oral glucose tolerance test were performed and plasma satiety hormones measured. The final body weight and the percentage of body fat were significantly affected by the interaction between maternal diet and offspring sex: weight and fat mass were higher in the female offspring of the HPv. HF dams. No differences in body weight or fat mass were seen in the male offspring. There was a significant sex effect for fasting and total AUC for ghrelin and fasting GIP, with females having higher levels than males. Liver TAG content and plasma NEFA were lower in the offspring of high-prebiotic fibre dams (HF1) than in those of high-protein dams (HP1) and control dams (C1). Intestinal expression ofGLUT2was decreased in HF1 and HP1v. C1. The maternal HP and HF diets had lasting effects on body fat and hepatic TAG accumulation in the offspring, particularly in females. Whereas the HP diet predisposes to an obese phenotype, the maternal HF diet appears to reduce the susceptibility to obesity following a high-energy diet challenge in adulthood. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5213612697BCF794EA6F6377E9FF6DE6/S0007114513000998a.pdf/div-class-title-a-maternal-high-protein-diet-predisposes-female-offspring-to-increased-fat-mass-in-adulthood-whereas-a-prebiotic-fibre-diet-decreases-fat-mass-in-rats-div.pdf |
| Ending Page | 1741 |
| Page Count | 10 |
| Starting Page | 1732 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114513000998 |
| Journal | British Journal Of Nutrition |
| Issue Number | 9 |
| Volume Number | 110 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2013-04-08 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics Prebiotic Fibre High Protein Diet Predisposes Female Offspring |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
