NDLI: Antiplatelet effect of new lipophilic hydroxytyrosol alkyl ether derivatives in human blood

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Antiplatelet effect of new lipophilic hydroxytyrosol alkyl ether derivatives in human blood

Content Provider	Springer Nature Link
Author	Reyes, J. J. La Cruz, J. P. Muñoz Marin, J. Guerrero, A. Lopez Villodres, J. A. Madrona, A. Espartero, J. L. Gonzalez Correa, J. A.
Copyright Year	2012
Abstract	To investigate the in vitro antiplatelet and anti-inflammatory effects of five alkyl hydroxytyrosol (HT) ether derivatives in human whole blood and compare these effects with those of HT.Blood samples from healthy volunteers were incubated with HT and HT alkyl ether derivatives (ethyl, butyl, hexyl, octyl and dodecyl). Maximum intensity of platelet aggregation was induced with collagen, arachidonic acid or ADP. Calcium-induced thromboxane B2 and nitric oxide production, LPS-induced prostaglandin E2 and nitric oxide production and LPS-induced interleukin 1β production were measured.All compounds inhibited platelet aggregation, thromboxane B2 and inflammatory mediators in a concentration-dependent manner. The concentrations of each compound that inhibited the corresponding variable by 50 % compared to control samples (IC50) were in the range of 10−7–10−6 M for HT hexyl ether; for the other compounds, these values were in the range of 10−5 M. The IC50 for thromboxane B2 production was in the range of 10−4 M. The effects of HT alkyl ether derivatives were greater than those of HT. These compounds increased nitric oxide production. There was no direct relationship between the effects of these compounds and alkyl chain length. Maximum effects were observed in the C4–C6 range.Alkyl ether derivatives of HT exert antiplatelet and anti-inflammatory effects that are greater than those of HT.
Starting Page	591
Ending Page	599
Page Count	9
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	52
Issue Number	2
e-ISSN	14366215
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-15
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hydroxytyrosol alkyl ether derivatives Platelet aggregation Prostanoids Nitric oxide Inflammatory mediators Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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