NDLI: Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women

Content Provider	Springer Nature Link
Author	López González, Ángel A. Grases, Félix Monroy, Nieves Marí, Bartolome Vicente Herrero, Mª Teófila Tur, Fernando Perelló, Joan
Copyright Year	2012
Abstract	The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women.A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76–1.42 μM) and 45 high (≥1.42 μM) urinary phytate concentrations. Densitometry values for neck were measured at enrollment and after 12 months (lumbar spine and femoral neck), and 10-year risk fracture was calculated using the tool FRAX®.Individuals with low InsP6 levels had significantly greater bone mass loss in the lumbar spine (3.08 ± 0.65 % vs. 0.43 ± 0.55 %) than did those with high phytate levels. Moreover, a significantly greater percentage of women with low than with high InsP6 levels showed more than 2 % of bone mass loss in the lumbar spine (55.6 vs. 20.7 %). The 10-year fracture probability was also significantly higher in the low-phytate group compared to the high-phytate group, both in hip (0.37 ± 0.06 % vs 0.18 ± 0.04 %) and major osteoporotic fracture (2.45 ± 0.24 % vs 1.83 ± 0.11 %).It can be concluded that high urinary phytate concentrations are correlated with reduced bone mass loss in lumbar spine over 12 months and with reduced 10-year probability of hip and major osteoporotic fracture, indicating that increased phytate consumption can prevent development of osteoporosis.
Starting Page	717
Ending Page	726
Page Count	10
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	52
Issue Number	2
e-ISSN	14366215
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bone mass loss Bone mineral density Osteoporosis Phytate Risk of fracture Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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