NDLI: The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules

Content Provider	Springer Nature Link
Author	Schunck, Tobias Herrero, Saturni Fischer, Reinhard
Copyright Year	2011
Abstract	Kinesin molecular motors serve a variety of cellular functions usually in dynamic processes. One characteristic feature of many kinesins is their ATP-dependent processive movement along polymerized microtubules. However, many kinesins work as stationary polymerases or depolymerases. Therefore, it needs to be determined for each motor, whether it moves processively along microtubules or not. The Schizosaccharomyces pombe kinesin-7, Tea2, has been shown to be involved in cell end marker transportation towards the cortex to organize the actin cytoskeleton. In human, kinesin 7 promotes microtubule polymerization. In Aspergillus nidulans, the machinery for determining growth directionality is conserved, but there is no evidence yet that kinesin 7, KipA is potentially involved in the transportation of the cell end marker proteins, TeaA or TeaR or newly identified proteins such as KatA. We expressed KipA in Escherichia coli and determined the catalytic properties of this kinesin. Here we show that KipA is an active ATPase, which is able to dimerize and move processively along microtubules with a speed of 9.48 μm/min.
Starting Page	335
Ending Page	341
Page Count	7
File Format	PDF
ISSN	01728083
Journal	Current Genetics
Volume Number	57
Issue Number	5
e-ISSN	14320983
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-07-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aspergillus Kinesin Tea2 KipA Plant Sciences Microbiology Proteomics Biochemistry Microbial Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules

The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore

The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity

A chitinase gene, chiB, involved in the autolytic process of Aspergillus nidulans

The veA gene is necessary for the negative regulation of the veA expression in Aspergillus nidulans

Isomaltose formed by α-glucosidases triggers amylase induction in Aspergillus nidulans

Single fungal kinesin motor molecules move processively along microtubules.

Consecutive gene deletions in Aspergillus nidulans: application of the Cre/loxP system

Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon

The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules

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The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules

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The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity

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The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules