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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 34
  3. Springer Seminars in Immunopathology : Volume 34, Issue 5, September 2012
  4. The future of food allergy therapeutics
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 34, Issue 6, November 2012
Springer Seminars in Immunopathology : Volume 34, Issue 5, September 2012
Introduction to Special Issue on Food Allergy
Innate immunostimulatory properties of allergens and their relevance to food allergy
Mucosal antibodies in the regulation of tolerance and allergy to foods
Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
Early life precursors, epigenetics, and the development of food allergy
Microbial regulation of allergic responses to food
Immunological mechanisms for desensitization and tolerance in food allergy
The future of food allergy therapeutics
Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding
Springer Seminars in Immunopathology : Volume 34, Issue 4, July 2012
Springer Seminars in Immunopathology : Volume 34, Issue 3, May 2012
Springer Seminars in Immunopathology : Volume 34, Issue 2, March 2012
Springer Seminars in Immunopathology : Volume 34, Issue 1, January 2012
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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The future of food allergy therapeutics

Content Provider Springer Nature Link
Author Henson, Michele Burks, A. Wesley
Copyright Year 2012
Abstract Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and growth delay as well as psychosocial burdens and the potential for fatal anaphylaxis. There is currently no effective form of therapy, and the mainstay of treatment remains strict avoidance. However, there are a number of promising therapeutic strategies currently being investigated for the treatment of food allergies. Allergen-specific approaches, such as various forms of immunotherapy, have been a major focus of investigation and appear to be promising methods of desensitization. More recently, the addition of anti-IgE monoclonal antibodies (mAbs) to immunotherapy regimens has been studied. Early work with antigen-fixed leukocytes in a murine model has shown promise in inducing tolerance, as have vaccines containing modified recombinant food proteins coadministered with heat-killed Escherichia coli. Nonspecific approaches include a Chinese herbal formulation, anti-IgE mAbs, and Trichuris suis ova therapy. The array of treatment modalities currently being investigated increases the likelihood of finding one or more effective therapies for the treatment of food allergy.
Starting Page 703
Ending Page 714
Page Count 12
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 34
Issue Number 5
e-ISSN 18632300
Language English
Publisher Springer-Verlag
Publisher Date 2012-06-27
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Food allergy Oral immunotherapy (OIT) Double-blind Placebo-controlled food challenge (DBPCFC) Anti-IgE antibody/omalizumab Desensitization Immunology Internal Medicine
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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