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| Content Provider | Springer Nature Link |
|---|---|
| Author | Berin, M. Cecilia |
| Copyright Year | 2012 |
| Abstract | The intestinal mucosa is densely packed with antibody-secreting B cells, the majority of which produce IgA. Mucosal antibodies have traditionally been thought of as neutralizing antibodies that exclude antigens, but they also function in antigen sampling, allowing for selective transcytosis of antigens from the intestinal lumen. IgE-mediated antigen uptake can facilitate the development of allergic reactions to foods, but emerging evidence indicates that IgG-mediated antigen uptake may also play an important role in the development of immune tolerance to foods, particularly in the neonate. This review will focus on the role of intestinal immunoglobulins in the development of clinical tolerance and allergy to food antigens. |
| Starting Page | 633 |
| Ending Page | 642 |
| Page Count | 10 |
| File Format | |
| ISSN | 18632297 |
| Journal | Springer Seminars in Immunopathology |
| Volume Number | 34 |
| Issue Number | 5 |
| e-ISSN | 18632300 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-07-10 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Epithelium Transcytosis Sensitization Tolerance Food allergy Immunology Internal Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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