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Springer Seminars in Immunopathology : Volume 39

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Introduction to Special Issue on Food Allergy

Innate immunostimulatory properties of allergens and their relevance to food allergy

Mucosal antibodies in the regulation of tolerance and allergy to foods

Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity

Early life precursors, epigenetics, and the development of food allergy

Microbial regulation of allergic responses to food

Immunological mechanisms for desensitization and tolerance in food allergy

The future of food allergy therapeutics

Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding

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Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity

Content Provider	Springer Nature Link
Author	Hogan, Simon P. Wang, Yui Hsi Strait, Richard Finkelman, Fred D.
Copyright Year	2012
Abstract	A food-induced anaphylactic reaction can occur within seconds to a few hours following exposure to the causal food allergen and often affects multiple organ systems including gastrointestinal, cutaneous, respiratory, and cardiovascular. A conundrum in the allergy field is that consumption of the same allergen can cause reactions of vastly different severity in separate individuals; one patient may experience a mild non-life-threatening reaction characterized by pruritis of lips or urticaria whereas another may experience a life-threatening reaction that involves respiratory and cardiovascular compromise leading to loss of consciousness and sometimes death. While there are tests available to determine the predictive risk value of a positive food challenge test or clinical reactivity, there is currently no reliable method to distinguish between individuals who are at risk of mild non-life-threatening versus life-threatening reaction. Recent research has significantly advanced our understanding of the involvement of immune pathways in the effector phase of food-induced anaphylaxis; a void remains regarding our understanding of the contribution of these pathways to severity of disease. In this review, we discuss mild non-life-threatening versus life-threatening food-induced anaphylaxis and factors (co-morbidities and immune activation) that predispose individuals to more severe disease. Furthermore, we summarize recent advancements in our understanding of the involvement of underlying immune pathways in systemic and food-induced anaphylaxis in mouse systems and discuss how these pathways may contribute to more severe disease phenotype.
Starting Page	643
Ending Page	653
Page Count	11
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	34
Issue Number	5
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mast cells Anaphylaxis Systemic Intestinal Mouse Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Food-induced Anaphylaxis: Mast Cells as Modulators of Anaphylactic Severity1

Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses

Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses (2011).

Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice

Increased Severity of Local and Systemic Anaphylactic Reactions in gp49B1-deficient Mice

Increased Severity of Local and Systemic Anaphylactic Reactions in gp49B1-deficient Mice (2001)

Multifactorial Modulation of Food-Induced Anaphylaxis

IgE and mast cells in host defense against parasites and venoms

A humanized mouse model of anaphylactic peanut allergy

Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity

Similar Documents

Food-induced Anaphylaxis: Mast Cells as Modulators of Anaphylactic Severity1

Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses

Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses (2011).

Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice

Increased Severity of Local and Systemic Anaphylactic Reactions in gp49B1-deficient Mice

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Multifactorial Modulation of Food-Induced Anaphylaxis

IgE and mast cells in host defense against parasites and venoms

A humanized mouse model of anaphylactic peanut allergy

Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity