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  1. Archivum Immunologiae et Therapiae Experimentalis
  2. Archivum Immunologiae et Therapiae Experimentalis : Volume 65
  3. Archivum Immunologiae et Therapiae Experimentalis : Volume 65, Issue 3, June 2017
  4. The Use of Omalizumab in Food Oral Immunotherapy
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Archivum Immunologiae et Therapiae Experimentalis : Volume 65
Archivum Immunologiae et Therapiae Experimentalis : Volume 65, Issue 3, June 2017
The Use of Omalizumab in Food Oral Immunotherapy
CD1: A Singed Cat of the Three Antigen Presentation Systems
Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations
CRISPR/Cas9 Immune System as a Tool for Genome Engineering
A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling
The Impact of Sex and Age on the Prevalence of Clinically Relevant Sensitization and Asymptomatic Sensitization in the General Population
Activated and Memory T Lymphocytes in Children with Gaucher Disease
MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
Archivum Immunologiae et Therapiae Experimentalis : Volume 65, Issue 2, April 2017
Archivum Immunologiae et Therapiae Experimentalis : Volume 65, Issue 1, February 2017
Archivum Immunologiae et Therapiae Experimentalis : Volume 64
Archivum Immunologiae et Therapiae Experimentalis : Volume 63
Archivum Immunologiae et Therapiae Experimentalis : Volume 62
Archivum Immunologiae et Therapiae Experimentalis : Volume 61
Archivum Immunologiae et Therapiae Experimentalis : Volume 60
Archivum Immunologiae et Therapiae Experimentalis : Volume 59
Archivum Immunologiae et Therapiae Experimentalis : Volume 58
Archivum Immunologiae et Therapiae Experimentalis : Volume 57
Archivum Immunologiae et Therapiae Experimentalis : Volume 56
Archivum Immunologiae et Therapiae Experimentalis : Volume 55
Archivum Immunologiae et Therapiae Experimentalis : Volume 54

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The Use of Omalizumab in Food Oral Immunotherapy

Content Provider Springer Nature Link
Author Labrosse, Roxane Graham, François Des Roches, Anne Bégin, Philippe
Copyright Year 2016
Abstract Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so far in routine practice. Oral immunotherapy (OIT) is a promising therapeutic alternative, but it is associated with frequent allergic reactions and cost-effectiveness issues. In hopes of reducing such reactions, a number of trials have used omalizumab, an anti-IgE monoclonal humanized antibody, as adjunctive therapy in OIT. The allergens studied in these omalizumab-enabled OIT trials include peanuts, milk, eggs, or mixes of multiple foods. In this article, we review the major findings from these studies and discuss potential benefits and issues related to omalizumab-enabled OIT. Results from the previous trials suggest that the use of omalizumab could potentially lead to safer and more efficient OIT protocols, by reducing the number and severity of reactions, and increasing allergen tolerance threshold. While more evidence is needed with regard to the maintenance of the long-term tolerance after OIT, omalizumab’s potential immunomodulatory role could be of benefit. More studies are needed to further document this new indication for omalizumab.
Starting Page 189
Ending Page 199
Page Count 11
File Format PDF
ISSN 0004069X
Journal Archivum Immunologiae et Therapiae Experimentalis
Volume Number 65
Issue Number 3
e-ISSN 16614917
Language English
Publisher Springer International Publishing
Publisher Date 2016-09-14
Publisher Place Cham
Access Restriction Subscribed
Subject Keyword Immunotherapy Desensitization Oral immunotherapy Food allergy Omalizumab Anti-IgE therapy Immunology Pharmacology/Toxicology
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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