NDLI: Microsatellite typing of the rhesus macaque MHC region

Content Provider	Springer Nature Link
Author	Penedo, M. Cecilia T. Bontrop, Ronald E. Heijmans, Corrine M. C. Otting, Nel ort, Riet Rouweler, Annemiek J. M. Groot, Nanine Groot, Natasja G. Ward, Thea Doxiadis, Gaby G. M.
Copyright Year	2005
Abstract	To improve the results gained by serotyping rhesus macaque major histocompatibility complex (MHC) antigens, molecular typing techniques have been established for class I and II genes. Like the rhesus macaque Mamu-DRB loci, the Mamu-A and -B are not only polymorphic but also polygenic. As a consequence, sequence-based typing of these genes is time-consuming. Therefore, eight MHC-linked microsatellites, or short tandem repeats (STRs), were evaluated for their use in haplotype characterization. Polymorphism analyses in rhesus macaques of Indian and Chinese origin showed high STR allelic diversity in both populations but different patterns of allele frequency distribution between the groups. Pedigree data for class I and II loci and the eight STRs allowed us to determine extended MHC haplotypes in rhesus macaque breeding groups. STR sequencing and comparisons with the complete rhesus macaque MHC genomic map allowed the exact positioning of the markers. Strong linkage disequilibria were observed between Mamu-DR and -DQ loci and adjacent STRs. Microsatellite typing provides an efficient, robust, and quick method of genotyping and deriving MHC haplotypes for rhesus macaques regardless of their geographical origin. The incorporation of MHC-linked STRs into routine genetic tests will contribute to efforts to improve the genetic characterization of the rhesus macaque for biomedical research and can provide comparative information about the evolution of the MHC region.
Starting Page	198
Ending Page	209
Page Count	12
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	57
Issue Number	3-4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-04-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MHC Non-human primates Evolution Microsatellites Haplotype
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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