NDLI: A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

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A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

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Immunogenetics : Volume 57, Issue 1-2, April 2005

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A new splicing acceptor site and poly(A)+ sequence signal within DQA10401 and DQA10501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

Content Provider	Springer Nature Link
Author	Hoarau, J. J. Festy, F. Cesari, M. Pabion, M.
Copyright Year	2005
Abstract	In this paper, we have analysed the diversity of mRNA species generated by DQA10501 and DQA10401 alleles in homozygous B-lymphoblastoid cell lines. As we previously reported, six mRNA isoforms that differ in the 3′UTR have been identified in these cells. This diversity of mRNA species results both from the alternative use of two acceptor spliced sites and the differential selection of two poly(A)+ sequence signals by the processing machinery. In this report we describe a new acceptor sequence signal that allows generation of a new alternative spliced mRNA species. This acceptor sequence signal was also present in all of the seven DQA1 homozygous cell lines analysed. In addition, we have identified a previously undetected, non-conventional but functional, poly(A)+ sequence signal that lacks an identifiable AATAAA hexamer, one of the most important element of the core. This sequence signal allows the generation of two additional mRNA isoforms both in DQA10501 and DQA10401 homozygous cell lines but not in the others. We show that DQA10501 and DQA10401 primary transcripts can be processed into nine mRNA isoforms that differ in the 3′UTR. Finally, we summarized all the DQA1 mRNA species deriving from DQA10101, DQA10102, DQA10103, DQA10201, DQA10301, DQA10401 and DQA1*0501 alleles and shown in B-lymphoblastoid cell lines.
Starting Page	182
Ending Page	188
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	57
Issue Number	3-4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-04-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Splicing Polyadenylation DQA1 gene 3′UTR Post-transcriptional regulation
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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A new splicing acceptor site and poly(A)+ sequence signal within DQA10401 and DQA10501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

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A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

A new splicing acceptor site and poly(A)+ sequence signal within DQA10401 and DQA10501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms