NDLI: Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer

Please wait, while we are loading the content...

A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3′UTR contribute to increase the extraordinary diversity of mRNA isoforms

Identification of the MHC class I B locus in cynomolgus monkeys

Microsatellite typing of the rhesus macaque MHC region

Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3

TRAV gene usage in pig T-cell receptor alpha cDNA

Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background

Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism

Host genes affect intestinal colonisation of newly hatched chickens by Campylobacter jejuni

Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes

MHC promoter polymorphism in grey wolves and domestic dogs

Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish

Structural and functional characterisation of the Toll like receptor 9 of Aotus nancymaae, a non-human primate model for malaria vaccine development

Single nucleotide polymorphisms within the promoter region of the rhesus monkey tumor necrosis factor-alpha gene

Fas has a role in cerebral malaria, but not in proliferation or exclusion of the murine parasite in mice

Immunogenetics : Volume 57, Issue 1-2, April 2005

Immunogenetics : Volume 56

Immunogenetics : Volume 55

Immunogenetics : Volume 54

Immunogenetics : Volume 53

Immunogenetics : Volume 52

Immunogenetics : Volume 51

Immunogenetics : Volume 50

Immunogenetics : Volume 49

Immunogenetics : Volume 48

Immunogenetics : Volume 47

Immunogenetics : Volume 46

Immunogenetics : Volume 45

Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer

Content Provider	Springer Nature Link
Author	Saha, Anjana Dhir, Ashish Ranjan, Anand Gupta, Vibhuti Bairwa, Narendra Bamezai, Ramesh
Copyright Year	2005
Abstract	Interferon (IFN)-γ is an important Th1 cytokine, which plays a role in immune surveillance and anti-tumor activity. A case-control study involving 54 sporadic breast cancer patients and 144 healthy controls was carried out to explore if the genotype variation of a proposed non-specific enhancer element with a dinucleotide (CA)n repeat in intron 1 has a role in the susceptibility to promote sporadic breast cancer. Genotype analysis carried out by single-strand length polymorphism and confirmed by sequencing showed an increased frequency of (CA)12 allele (P<0.001) and decreased frequencies of (CA)15 (P<0.01) and (CA)>15 (p<0.001) alleles in sporadic breast cancer patients as compared to controls. Further, in vitro reporter assays for (CA)12 and (CA)15 alleles suggested these to be associated with decreased and increased expressions, respectively, suggesting the (CA)12/(CA)12 background to act as one of the factors that could lead to low production of IFN-γ. The study concludes that such genetic background for a proposed non-specific enhancer element with (CA)n repeat within intron 1 of the IFNG gene might put the individuals with this genotype at higher risk to promote the development of sporadic breast cancer due to a resultant compromised immune surveillance.
Starting Page	165
Ending Page	171
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	57
Issue Number	3-4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-03-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Interferon-γ Polymorphism Expression Breast cancer
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer

Association of polymorphisms in intron 2 of FGFR2 and breast cancer risk in Chinese women

Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis

Genetic Polymorphism of Interferon-γ, Interferon-γ Receptor, and Interferon Regulatory Factor-1 Genes in Patients with Hepatitis B Virus Infection

Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosis.

Polymorphism in intron 1 of the interferon-gamma gene influences both serum immunoglobulin E levels and the risk for chronic hepatitis B virus infection in Polynesians

The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual’s susceptibility to sporadic colorectal cancer

A regulatory polymorphism in interferon-γ receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection

Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer

Similar Documents

Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer

Association of polymorphisms in intron 2 of FGFR2 and breast cancer risk in Chinese women

Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis

Genetic Polymorphism of Interferon-γ, Interferon-γ Receptor, and Interferon Regulatory Factor-1 Genes in Patients with Hepatitis B Virus Infection

Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosis.

Polymorphism in intron 1 of the interferon-gamma gene influences both serum immunoglobulin E levels and the risk for chronic hepatitis B virus infection in Polynesians

The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual’s susceptibility to sporadic colorectal cancer

A regulatory polymorphism in interferon-γ receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection

Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer