NDLI: Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish

Content Provider	Springer Nature Link
Author	Hikima, Jun ichi Middleton, Darlene L. Wilson, Melanie R. Miller, rman W. Clem, L. William Warr, Gregory W.
Copyright Year	2005
Abstract	The function of the transcriptional enhancer, Eμ3′, of the IgH locus of the channel catfish, Ictalurus punctatus, involves the interaction of E-protein and Oct family transcription factors. The E-proteins [class I basic helix–loop–helix (bHLH) family] are encoded in mammals by three genes: E2A (of which E12/E47 are alternatively spliced products), HEB, and E2-2. An E2A homologue has been identified in a catfish B-cell cDNA library and contains regions homologous to the bHLH and activation domains of mammalian and other vertebrate E2A proteins. E2A message is widely expressed, being readily detected in catfish B cells, T cells, kidney, spleen, brain, and muscle. Its expression is lower than that previously observed for TF12/CFEB, the catfish homologue of HEB. E2A strongly activated transcription of a μE5 motif-dependent construct in catfish B cells, and also activated transcription from the core region of the catfish IgH enhancer (Eμ3′) in a manner dependent on the presence of the μE5 site. Catfish E2A, expressed in vitro, bound the μE5 motif present in the core region of Eμ3′. These results document the conservation of structure and function in vertebrate E2A and suggest a potential role of E2A in driving expression of the IgH locus at the phylogenetic level of a teleost fish.
Starting Page	273
Ending Page	282
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	57
Issue Number	3-4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-04-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Catfish E2A Transcription factor Gene regulation Immunoglobulin
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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