NDLI: Study of cynomolgus monkey (Macaca fascicularis) DRA polymorphism in four populations

Content Provider	Springer Nature Link
Author	Aarnink, Alice Estrade, Laurent Apoil, Pol André Kita, Yuki F. Saitou, Naruya Shiina, Takashi Blancher, Antoine
Copyright Year	2010
Abstract	To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not been described until now. In the Mauritius population, we confirmed the presence of three DRA alleles. In the Philippine and Vietnam populations, we observed 11 and 14 DRA alleles, respectively. Only two alleles were present in all three populations. All DRA alleles but one differ from the consensus sequence by one to three mutations, most being synonymous; so, only seven DR alpha proteins were deduced from the 22 cDNA alleles. One DRA cDNA allele, Mafa-DRA02010101, differs from all other alleles by 11 to 14 mutations of which only four are non-synonymous. The two amino acid changes inside the peptide groove of Mafa-DRA02010101 are highly conservative. The very low proportion of non-synonymous/synonymous mutations is compatible with a purifying selection which is comparable to all previous observations concerning the evolution of the DRA gene in mammals. Homologues of the allele Mafa-DRA*02010101 are also found in two other Asian macaques (Macaca mulatta and Macaca nemestrina). The forces able to maintain this highly divergent allele in three different macaque species remain hypothetical.
Starting Page	123
Ending Page	136
Page Count	14
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	62
Issue Number	3
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MHC DRA Macaque Polymorphism Allergology Gene Function Cell Biology Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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