NDLI: Impact of MHC class II polymorphism on blood counts of CD4+ T lymphocytes in macaque

Content Provider	Springer Nature Link
Author	Aarnink, Alice Garchon, Henri Jean Puissant Lubra, Bénédicte Blancher Sardou, Marie Apoil, Pol André Blancher, Antoine
Copyright Year	2010
Abstract	While the number of peripheral blood T lymphocytes and of their two main subsets (CD4+CD8− and CD4−CD8+) varies little in a given healthy individual, substantial variation is observed between individuals. It was proposed that these counts could be influenced by MHC polymorphisms because of the well-established role of MHC molecules in thymic T lymphocyte maturation and presentation of antigenic peptides to peripheral T lymphocytes. To test this hypothesis, we have chosen the crab-eating macaque (Macaca fascicularis), an animal model phylogenetically close to man. We selected the Philippine macaque population because of a restriction of the MHC polymorphism in this islander population. Peripheral blood lymphocytes were counted with an automated analyzer and T lymphocyte subsets were assessed by immunolabeling and flow cytometry. The MHC polymorphism was investigated in 200 unrelated subjects using 14 microsatellites markers distributed across the MHC and the DRB locus that was genotyped by denaturing gradient gel electrophoresis and sequencing. All markers were in Hardy–Weinberg equilibrium. Allelic associations were tested with the UNPHASED software. We revealed a significant influence of the MHC class II region on CD4+ T lymphocyte blood count with the largest effect associated with a two-locus haplotypes combining the DRACA allele 274 and the DRB haplotype #8a (p < 8 × 10−7). Our data should stimulate a similar association study of the CD4+ T cell counts in humans.
Starting Page	95
Ending Page	102
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	63
Issue Number	2
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-11-18
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MHC Microsatellites DRB CD4+ T lymphocytes Cynomolgus macaque Macaca fascicularis Allergology Gene Function Cell Biology Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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