NDLI: Identification and functional perspective of a novel HLA-A allele: A*0279

Content Provider	Springer Nature Link
Author	Liu, Fangfang Wang, Shan Ye, Yingjiang Zhang, Huagang Zhang, Yu Chen, Weifeng
Copyright Year	2006
Abstract	A novel HLA-A allele, HLA-A0279, was identified using PCR-SSP and PCR-SBT methods. It is inheritable. HLA-A0279 differs from HLA-A020601 by a single nucleotide at position 497 in exon 3, leading to an amino acid change from Threonine to Isoleucine at the alpha2 helix of HLA molecule. To investigate whether the altered amino acid residue could affect its peptide-binding repertoire, we compared the predicted crystal structure of HLA-A020601 and HLA-A0279 by Swiss-PdbViewer software analysis. We found that the crystal structure of the two molecules is very similar except for a difference in the number of hydrogen bonds they can possibly form, which in turn could affect their structural stability. To test whether HLA-A0279 has the ability to cross-present A0201 - restricted peptides to T cells, the full lenght cDNA of HLA-A0201, -A* 020601 and -A0279 were respectively transfected into COS-7 cells, which were then used as targets in IFN-gamma release Elispot assay. A2079 was found to be able to present A*0201- restricted peptides to and induce the response of CTL, thus it can be classified as member of the HLA-A2 functional supertype family. This finding would benefit the design of peptide vaccines to be applied in broader populations.
Starting Page	339
Ending Page	346
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	5-6
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-04-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HLA-A supertype Cytotoxic T lymphocytes Elispot assay Crystal structure Allergology Cell Biology Gene Function Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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