NDLI: Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques

Content Provider	Springer Nature Link
Author	Groot, Natasja G. Heijmans, Corrine M. C. Ru, Arud H. Hassan, Chopie Otting, Nel Doxiadis, Gaby G. M. Koning, Frits Veelen, Peter A. Bontrop, Ronald E.
Copyright Year	2013
Abstract	Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.
Starting Page	897
Ending Page	900
Page Count	4
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	65
Issue Number	12
e-ISSN	14321211
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-09-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rhesus macaque HIV HLA MHC peptidomics Polymorphism Supertype Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A102601 and Mamu-B08301 reveals HLA-A2 and HLA-A3 supertypic specificities

Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A102601 and Mamu-B08301 reveals HLA-A2 and HLA-A3 supertypic specificities

The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype

The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype

Identification of MHC class I sequences in Chinese-origin rhesus macaques

A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules

A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules

The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype

Diversity of MHC class I genes in Burmese-origin rhesus macaques

Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques

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