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Promotion of cell proliferation by the proto‐oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nakashima, Takayuki Tomita, Hiroyuki Hirata, Akihiro Ishida, Kazuhisa Hisamatsu, Kenji Hatano, Yuichiro Kanayama, Tomohiro Niwa, Ayumi Noguchi, Kei Kato, Keizo Miyazaki, Tatsuhiko Tanaka, Takuji Shibata, Toshiyuki Hara, Akira |
| Copyright Year | 2017 |
| Abstract | Oral squamous cell carcinoma (OSCC) develops through a multistep carcinogenic process involving field cancerization. The DEK gene is a proto-oncogene with functions in genetic and epigenetic modifications, and has oncogenic functions, including cellular proliferation, differentiation, and senescence. DEK overexpression is associated with malignancies; however, the functional roles of DEK overexpression are unclear. We demonstrated that DEK-expressing cells were significantly increased in human dysplasia/carcinoma in situ and OSCC. Furthermore, we generated ubiquitous and squamous cell-specific doxycycline (DOX)-inducible Dek mice (iDek and iDek-e mice respectively). Both DOX+ iDek and iDek-e mice did not show differences in the oral mucosa compared with DOX- mice. In the environment exposed to carcinogen, DOX-treated (DOX+) iDek mice showed field cancerization and OSCC development. Microarray analysis revealed that DEK overexpression was mediated by the upregulation of DNA replication- and cell cycle-related genes, particularly those related to the G1 /S transition. Tongue tumors overexpressing DEK showed increased proliferating cell nuclear antigen and elongator complex protein 3 expression. Our data suggest that DEK overexpression enhanced carcinogenesis, including field cancerization, in OSCC by stimulating the G1 /S phase transition and promoting DNA replication, providing important insights into the potential applications of DEK as a target in the treatment and prevention of OSCC. |
| Starting Page | 2424 |
| Ending Page | 2439 |
| Page Count | 16 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28834425v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/cam4.1157 |
| DOI | 10.1002/cam4.1157 |
| Journal | Cancer medicine |
| Volume Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antigens, Nuclear Carcinogenesis Carcinogens Carcinoma in Situ Cell Proliferation DNA Replication Dek protein, human Doxorubicin Doxycycline Hyperplasia Leukemia, B-Cell Liver carcinoma Neoplasms Oncogenes Phase Transition Proliferating Cell Count Promotion (action) Proto-Oncogenes Squamous Epithelial Cells Squamous cell carcinoma Stimulation (motivation) Up-Regulation (Physiology) study of epigenetics |
| Content Type | Text |
| Resource Type | Article |
