Loading...
Please wait, while we are loading the content...
Similar Documents
Complex effects of Ras proto-oncogenes in tumorigenesis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Diaz, Roberto Lopez-Barcons, Lluis- Ahn, David K. García-España, Antonio Yoon, Andrew Matthews, Jeremy Mangues, Ramón Perez-Soler, R. Pellicer, Angel |
| Copyright Year | 2004 |
| Abstract | Ras proteins have been found mutated in about one-third of human tumors. In vitro, Ras has been shown to regulate distinct and contradictory effects, such as cellular proliferation and apoptosis. Nonetheless, the effects that the wild-type protein elicits in tumorigenesis are poorly understood. Depending on the type of tissue, Ras proto-oncogenes appear to either promote or inhibit the tumor phenotype. In this report, we treated wild-type and N-ras knockout mice with 3-methylcholanthrene (MCA) to induce fibrosarcomas and found that MCA is more carcinogenic in wild-type mice than in knockout mice. After injecting different doses of a tumorigenic cell line, the wild-type mice exhibited a shorter latency of tumor development than the knockouts, indicating that there are N-ras-dependent differences in the stromal cells. Likewise, we have analyzed B-cell lymphomas induced by either N-methylnitrosourea or by the N-ras oncogene in mice that over-express the N-ras proto-oncogene and found that the over-expression of wild-type N-ras is able to increase the incidence of these lymphomas. Considered together, our results indicate that Ras proto-oncogenes can enhance or inhibit the malignant phenotype in vivo in different systems. |
| Starting Page | 385 |
| Ending Page | 386 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/bgh026.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAaYwggGiBgkqhkiG9w0BBwagggGTMIIBjwIBADCCAYgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8EIKCznkFB5GnfJeAgEQgIIBWTMKwtofhdOk4ZqUlS8FIyHUpkZLhgAHNnTIdl-fQVaq6xJuGKpLI7MOZrVB9wHdLWxjeKVeo0B_7_zuoIAByWe6YzySdq29gg_NVGH3Djcy2eYNAhQKQ6YVB1vmos-rBTIxDd776p73vbmSxFbJpVumpFPWxlsnKZPeuRs_dKyV6jo-IIh9y0unz8tASh1I3ZszStt-duLnMSWptM5WdoVBcpVeTOTBZ_wxhRdudoGqWJsWmvP296kyhUcpFHYwy6_D1Pbq7nmbZgVEqB4wI_NvCcsSq-vR7glJ9f8NGxrSAjEUScj7Hvxv01jy1pobXKwrV4e1NZ7LeojLESy1EFkTJzFbQPNSp_Pljzu0Ma6bGPLQi6GoOhoB8p5sCknqZZ9j0Cwhy-VBjTWYngKYECJcZ19hKEFyTNQ7eXEwECazZrOETnrhRfFw6MPBsiWWDImA1_xajmS15A |
| PubMed reference number | 14633661v1 |
| Volume Number | 25 |
| Issue Number | 4 |
| Journal | Carcinogenesis |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 20-Methylcholanthrene Apoptosis B-Cell Lymphomas Carcinogenesis Cell Proliferation Fibrosarcoma Hyperplasia Leukemia, B-Cell Lymphoma Methylnitrosourea Neoplasms Oncogenes Proto-Oncogenes ras Oncogene |
| Content Type | Text |
| Resource Type | Article |
