Role of the DEK oncogene in the development of squamous cell carcinoma.

Content Provider	Europe PMC
Author	Ishida, Kazuhisa Nakashima, Takayuki Shibata, Toshiyuki Hara, Akira Tomita, Hiroyuki
Abstract	DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous cell carcinoma (SCC) and is useful for early diagnosis of the disease. These findings have made DEK an attractive therapeutic target, especially for human papillomavirus (HPV)-associated SCC. However, the mechanism of DEK in SCC remains unclear. In this review, we discuss human DEK oncogene-related SCC.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7441080&blobtype=pdf
ISSN	13419625
Journal	International Journal of Clinical Oncology [Int J Clin Oncol]
Volume Number	25
DOI	10.1007/s10147-020-01735-5
PubMed Central reference number	PMC7441080
Issue Number	9
PubMed reference number	32656741
e-ISSN	14377772
Language	English
Publisher	Springer Singapore
Publisher Date	2020-07-12
Publisher Place	Singapore
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
Subject Keyword	DEK Oncogene Squamous cell carcinoma
Content Type	Text
Resource Type	Article
Subject	Hematology Surgery Oncology